Syeda F Husain1,2, Samantha K Ong3, Liu Cuizhen4, Bach Tran5,6,7, Roger C Ho1,2, Cyrus S Ho2. 1. Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore. 2. Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3. Department of Psychological Medicine, National University Health System, Singapore. 4. Department of Psychology, Faculty of Arts and Social Science, National University of Singapore, Singapore. 5. Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. 6. Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam. 7. Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam.
Abstract
OBJECTIVE: Patients with major depressive disorder tend to exhibit poorer decision-making capacity than the general population, but neurobiological evidence is lacking. Functional near-infrared spectroscopy monitors changes in oxy-haemoglobin concentration in the cerebral cortex. It may provide an objective assessment of neurophysiological responses during decision-making processes. Thus, this study investigated the effect of major depressive disorder diagnosis and severity on prefrontal cortex activity during the Iowa gambling task. METHODS: Right-handed healthy controls (n = 25) and patients with major depressive disorder (n = 25) were matched for age, gender, ethnicity and years of education in this cross-sectional study. Functional near-infrared spectroscopy signals and the responses made during a computerised Iowa gambling task were recorded. In addition, demographics, clinical history and symptom severity were noted. RESULTS: Compared to healthy controls, patients with major depressive disorder had reduced haemodynamic response in several cortical regions of the frontal lobe (Hedge's g range from 0.71 to 1.52; p values range from ⩽0.001 to 0.041). Among patients, mean oxy-haemoglobin declined with major depressive disorder severity in the right orbitofrontal cortex (Pearson's r = -0.423; p = 0.024). CONCLUSION: Haemodynamic dysfunction of the prefrontal cortex during decision-making processes is associated with major depressive disorder diagnosis and severity. These neurophysiological alterations may have a role in the decision-making capacity of patients with major depressive disorder.
OBJECTIVE:Patients with major depressive disorder tend to exhibit poorer decision-making capacity than the general population, but neurobiological evidence is lacking. Functional near-infrared spectroscopy monitors changes in oxy-haemoglobin concentration in the cerebral cortex. It may provide an objective assessment of neurophysiological responses during decision-making processes. Thus, this study investigated the effect of major depressive disorder diagnosis and severity on prefrontal cortex activity during the Iowa gambling task. METHODS: Right-handed healthy controls (n = 25) and patients with major depressive disorder (n = 25) were matched for age, gender, ethnicity and years of education in this cross-sectional study. Functional near-infrared spectroscopy signals and the responses made during a computerised Iowa gambling task were recorded. In addition, demographics, clinical history and symptom severity were noted. RESULTS: Compared to healthy controls, patients with major depressive disorder had reduced haemodynamic response in several cortical regions of the frontal lobe (Hedge's g range from 0.71 to 1.52; p values range from ⩽0.001 to 0.041). Among patients, mean oxy-haemoglobin declined with major depressive disorder severity in the right orbitofrontal cortex (Pearson's r = -0.423; p = 0.024). CONCLUSION: Haemodynamic dysfunction of the prefrontal cortex during decision-making processes is associated with major depressive disorder diagnosis and severity. These neurophysiological alterations may have a role in the decision-making capacity of patients with major depressive disorder.
Authors: Diego M Davila-Torres; Gabriela E Vilcas-Solís; Mery Rodríguez-Vásquez; Yaquelin E Calizaya-Milla; Jacksaint Saintila Journal: SAGE Open Med Date: 2021-09-01
Authors: Aaron Shengting Mai; Oliver Zi Hern Lim; Yeung Jek Ho; Gwyneth Kong; Grace En Hui Lim; Cheng Han Ng; Cyrus Ho; Roger Ho; Yinghao Lim; Ivandito Kuntjoro; Edgar Tay; James Yip; Nicholas W S Chew; Ting-Ting Low Journal: Front Med (Lausanne) Date: 2022-02-17