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Literature DB >> 33298734

A Perspective on Personalized Therapies in Hypertrophic Cardiomyopathy.

Paul H Goldspink¹, Chad M Warren¹, Jan Kitajewski¹, Beata M Wolska^1,2, R John Solaro¹.

Abstract

ABSTRACT: A dominant mechanism of sudden cardiac death in the young is the progression of maladaptive responses to genes encoding proteins linked to hypertrophic cardiomyopathy. Most are mutant sarcomere proteins that trigger the progression by imposing a biophysical defect on the dynamics and levels of myofilament tension generation. We discuss approaches for personalized treatments that are indicated by recent advanced understanding of the progression.

Entities: Chemical

Mesh：

Year: 2021 PMID： 33298734 PMCID： PMC7933064 DOI： 10.1097/FJC.0000000000000968

Source DB: PubMed Journal: J Cardiovasc Pharmacol ISSN： 0160-2446 Impact factor: 3.271

54 in total

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2 in total

1. Novel insights into sarcomere regulatory systems control of cardiac thin filament activation.

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2 in total