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Literature DB >> 33297368

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV.

Maria Anele Romeo^1,2, Roberta Santarelli^1,2, Maria Saveria Gilardini Montani^1,2, Roberta Gonnella^1,2, Rossella Benedetti^1,2, Alberto Faggioni^1,2, Mara Cirone^1,2.

Abstract

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.

Entities: CellLine Chemical Disease Gene Species

Keywords: AD; DCs; EBV; HHV-6; KSHV; ROS; UPR; autophagy; cancer

Mesh：

Substances：
Reactive Oxygen Species

Year: 2020 PMID： 33297368 PMCID： PMC7762304 DOI： 10.3390/cells9122624

Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600

44 in total

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3. Epstein-barr virus blocks the autophagic flux and appropriates the autophagic machinery to enhance viral replication.

Authors: Marisa Granato; Roberta Santarelli; Antonella Farina; Roberta Gonnella; Lavinia Vittoria Lotti; Alberto Faggioni; Mara Cirone
Journal: J Virol Date: 2014-08-20 Impact factor: 5.103

4. BFRF1 protein is involved in EBV-mediated autophagy manipulation.

Authors: Roberta Gonnella; Marzia Dimarco; Giuseppina A Farina; Roberta Santarelli; Sandro Valia; Alberto Faggioni; Antonio Angeloni; Mara Cirone; Antonella Farina
Journal: Microbes Infect Date: 2020-09-01 Impact factor: 2.700

5. Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies.

Authors: Gabriella D'Orazi; Marco Cordani; Mara Cirone
Journal: Cell Mol Life Sci Date: 2020-10-17 Impact factor: 9.261

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Journal: Virology Date: 2018-07-24 Impact factor: 3.616

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Authors: Dharam Ablashi; Henri Agut; Roberto Alvarez-Lafuente; Duncan A Clark; Stephen Dewhurst; Dario DiLuca; Louis Flamand; Niza Frenkel; Robert Gallo; Ursula A Gompels; Per Höllsberg; Steven Jacobson; Mario Luppi; Paolo Lusso; Mauro Malnati; Peter Medveczky; Yasuko Mori; Philip E Pellett; Joshua C Pritchett; Koichi Yamanishi; Tetsushi Yoshikawa
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Review 2. Regulation of the Macroautophagic Machinery, Cellular Differentiation, and Immune Responses by Human Oncogenic γ-Herpesviruses.

Authors: Christian Münz
Journal: Viruses Date: 2021-05-08 Impact factor: 5.048

2 in total