Literature DB >> 33296281

The complex role of prostaglandin E2-EP receptor signaling in wound healing.

Kristy E Gilman1, Kirsten H Limesand1.   

Abstract

Prostaglandins are critical lipid mediators involved in the wound healing response, with prostaglandin E2 (PGE2) being the most complex and exhibiting the most diverse physiological outputs. PGE2 signals via four G protein-coupled receptors, termed EP-receptors 1-4 that induce distinct signaling pathways upon activation and lead to an array of different outputs. Recent studies examining the role of PGE2 and EP receptor signaling in wound healing following various forms of tissue damage are discussed in this review.

Entities:  

Keywords:  cell signaling; prostaglandins; repair; tissue damage; wound healing

Mesh：

Substances：

Year:  2020        PMID： 33296281      PMCID： PMC7988772          DOI： 10.1152/ajpregu.00185.2020

Source DB:  PubMed          Journal:  Am J Physiol Regul Integr Comp Physiol        ISSN： 0363-6119            Impact factor:   3.619


  34 in total

Review 1.  Multifaceted roles of PGE2 in inflammation and cancer.

Authors:  Masako Nakanishi; Daniel W Rosenberg
Journal:  Semin Immunopathol       Date:  2012-09-21       Impact factor: 9.623

2.  VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure.

Authors:  Hu Xu; Shengnan Du; Bingying Fang; Chaojie Li; Xiao Jia; Senfeng Zheng; Sailun Wang; Qingwei Li; Wen Su; Nanping Wang; Feng Zheng; Lihong Chen; Xiaoyan Zhang; Jan-Åke Gustafsson; Youfei Guan
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-04       Impact factor: 11.205

3.  Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.

Authors:  Huifeng Hao; Sheng Hu; Qing Wan; Chuansheng Xu; Hong Chen; Liyuan Zhu; Zhenyu Xu; Jian Meng; Richard M Breyer; Nailin Li; De-Pei Liu; Garret A FitzGerald; Miao Wang
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-03-29       Impact factor: 8.311

4.  Arachidonic acid-derived signaling lipids and functions in impaired healing.

Authors:  Sandeep Dhall; Dayanjan Shanaka Wijesinghe; Zubair A Karim; Anthony Castro; Hari Priya Vemana; Fadi T Khasawneh; Charles E Chalfant; Manuela Martins-Green
Journal:  Wound Repair Regen       Date:  2015-09-14       Impact factor: 3.617

Review 5.  Eicosanoid storm in infection and inflammation.

Authors:  Edward A Dennis; Paul C Norris
Journal:  Nat Rev Immunol       Date:  2015-07-03       Impact factor: 53.106

Review 6.  Prostaglandin E receptors.

Authors:  Yukihiko Sugimoto; Shuh Narumiya
Journal:  J Biol Chem       Date:  2007-02-28       Impact factor: 5.157

7.  CREB pathway links PGE2 signaling with macrophage polarization.

Authors:  Bing Luan; Young-Sil Yoon; John Le Lay; Klaus H Kaestner; Susan Hedrick; Marc Montminy
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-07       Impact factor: 11.205

8.  Prostaglandin E2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor.

Authors:  F Gregory Buchanan; Dingzhi Wang; Francesca Bargiacchi; Raymond N DuBois
Journal:  J Biol Chem       Date:  2003-06-24       Impact factor: 5.157

9.  Prostaglandin E2 sequentially activates E-prostanoid receptor-3 and thromboxane prostanoid receptor to evoke contraction and increase in resistance of the mouse renal vasculature.

Authors:  Bin Liu; Xiangzhong Wu; Ruhui Zeng; Yehu Yin; Tingting Guo; Yineng Xu; Yingzhan Zhang; Jing Leng; Jiahui Ge; Gang Yu; Jinwei Guo; Yingbi Zhou
Journal:  FASEB J       Date:  2019-12-18       Impact factor: 5.191

10.  Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease.

Authors:  Ling-Shiang Chuang; Joshua Morrison; Nai-Yun Hsu; Philippe Ronel Labrias; Shikha Nayar; Ernie Chen; Nicole Villaverde; Jody Ann Facey; Gilles Boschetti; Mamta Giri; Mireia Castillo-Martin; Tin Htwe Thin; Yashoda Sharma; Jaime Chu; Judy H Cho
Journal:  Dis Model Mech       Date:  2019-08-13       Impact factor: 5.758
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  4 in total

1.  Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues.

Authors:  Li Li; Rongjin Sun; Joseph Zenga; Heather Himburg; Lu Wang; Shengnan Duan; Jingwen Liu; Dinh Bui; Zuoxu Xie; Ting Du; Lijun Xie; Taijun Yin; Stu Wong; Song Gao; Ming Hu
Journal:  J Inflamm Res       Date:  2022-08-04

2.  NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function.

Authors:  Eugenia Martin Vázquez; Nadia Cobo-Vuilleumier; Raquel Araujo Legido; Sandra Marín-Cañas; Emanuele Nola; Akaitz Dorronsoro; Lucia López Bermudo; Alejandra Crespo; Silvana Y Romero-Zerbo; Maria García-Fernández; Alejandro Martin Montalvo; Anabel Rojas; Valentine Comaills; Francisco J Bérmudez-Silva; Maureen Gannon; Franz Martin; Decio Eizirik; Petra I Lorenzo; Benoit R Gauthier
Journal:  iScience       Date:  2022-05-02

3.  Exploring Relevant mRNAs and miRNAs in Injured Urethral Tissues of Rats with High-Throughput Sequencing.

Authors:  Han Lin; Shiyong Guo; Song Li; Jihong Shen; Jianfeng He; Yun Zheng; Zhenhua Gao
Journal:  Genes (Basel)       Date:  2022-05-05       Impact factor: 4.141

4.  Indomethacin Treatment Post-irradiation Improves Mouse Parotid Salivary Gland Function via Modulation of Prostaglandin E2 Signaling.

Authors:  Kristy E Gilman; Jean M Camden; Lucas T Woods; Gary A Weisman; Kirsten H Limesand
Journal:  Front Bioeng Biotechnol       Date:  2021-07-21
  4 in total

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