Buğra Kerget1, Ferhan Kerget2, Ahmet Kızıltunç3, Abdullah Osman Koçak4, Ömer Araz1, Elif Yılmazel Uçar1, Metin Akgün1. 1. Department of Pulmonary Diseases, School of Medicine, Ataturk University, Erzurum, Turkey. 2. Department of Infection Diseases and Clinical Microbiology, Health Science University, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. 3. Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. 4. Department of Emergency Medicine, School of Medicine, Ataturk University, Erzurum, Turkey.
Abstract
INTRODUCTION: SARS-CoV-2 (COVID-19), which emerged in Wuhan, China in December 2019, infected more than six million people in a short time. In COVID-19, the relationship of many laboratory parameters to morbidity and mortality has been defined. In our study, we aimed to determine the relationship of serum vitamin D level to clinical course and prognosis. MATERIALS AND METHODS: This study included 108 patients; 88 patients who stayed in Ataturk University and Erzurum City Hospital between March 24, 2020 and May 15, 2020, who were identified as COVID-19 by real-time PCR method from the nasopharyngeal swab and 20 asymptomatic voluntary medical personnel who tested negative for real-time PCR after routine check-up in our hospital. RESULT: In statistical analysis conducted between healthy control group and vitamin D levels of patients admitted due to COVID-19, it was observed that patients infected with COVID-19 had a lower level (p= 0.004). In 20 patients developing MAS, a lower level of vitamin D was observed (p= 0.004) compared to 68 patients who did not develop. In the comparison of vitamin D levels of the patients (n= 8) who developed exitus in their follow up due to COVID-19, it was observed that vitamin D levels were statistically significantly lower compared to the living (p= 0.009). CONCLUSIONS: Due to COVID-19, pandemic, long-running quarantines caused insufficient use of sunlight and worsening of vitamin D deficiency. We wanted to draw attention again with our study to vitamin D which can be responsible for the heavy clinical course of COVID-19 and whose replacement is easy to apply.
INTRODUCTION: SARS-CoV-2 (COVID-19), which emerged in Wuhan, China in December 2019, infected more than six million people in a short time. In COVID-19, the relationship of many laboratory parameters to morbidity and mortality has been defined. In our study, we aimed to determine the relationship of serum vitamin D level to clinical course and prognosis. MATERIALS AND METHODS: This study included 108 patients; 88 patients who stayed in Ataturk University and Erzurum City Hospital between March 24, 2020 and May 15, 2020, who were identified as COVID-19 by real-time PCR method from the nasopharyngeal swab and 20 asymptomatic voluntary medical personnel who tested negative for real-time PCR after routine check-up in our hospital. RESULT: In statistical analysis conducted between healthy control group and vitamin D levels of patients admitted due to COVID-19, it was observed that patients infected with COVID-19 had a lower level (p= 0.004). In 20 patients developing MAS, a lower level of vitamin D was observed (p= 0.004) compared to 68 patients who did not develop. In the comparison of vitamin D levels of the patients (n= 8) who developed exitus in their follow up due to COVID-19, it was observed that vitamin D levels were statistically significantly lower compared to the living (p= 0.009). CONCLUSIONS: Due to COVID-19, pandemic, long-running quarantines caused insufficient use of sunlight and worsening of vitamin D deficiency. We wanted to draw attention again with our study to vitamin D which can be responsible for the heavy clinical course of COVID-19 and whose replacement is easy to apply.
Authors: Jimmy T Efird; Ethan J Anderson; Charulata Jindal; Thomas S Redding; Andrew D Thompson; Ashlyn M Press; Julie Upchurch; Christina D Williams; Yuk Ming Choi; Ayako Suzuki Journal: Int J Environ Res Public Health Date: 2021-12-31 Impact factor: 3.390
Authors: Andrea Crafa; Rossella Cannarella; Rosita A Condorelli; Laura M Mongioì; Federica Barbagallo; Antonio Aversa; Sandro La Vignera; Aldo E Calogero Journal: EClinicalMedicine Date: 2021-10-20
Authors: Sebastian T Lugg; William R Mackay; Aduragbemi A Faniyi; Sian E Faustini; Craig Webster; Joanne E Duffy; Martin Hewison; Adrian M Shields; Dhruv Parekh; Alex G Richter; Aaron Scott; David R Thickett Journal: BMJ Open Respir Res Date: 2022-09
Authors: Andrea Crafa; Rossella Cannarella; Rosita A Condorelli; Laura M Mongioì; Federica Barbagallo; Antonio Aversa; Sandro La Vignera; Aldo E Calogero Journal: EClinicalMedicine Date: 2021-06-18