Literature DB >> 3329536

Hormone-sensitive lipase in brown adipose tissue: identification and effect of cold exposure.

C Holm1, G Fredrikson, B Cannon, P Belfrage.   

Abstract

Hormone-sensitive lipase (HSL) in brown adipose tissue from mice was identified through immunoprecipitation with a polyclonal antibody (anti-HSL) towards rat white fat HSL and Western blotting. An 82 kDa polypeptide, slightly smaller than the rat white fat HSL 84 kDa subunit, was detected and its identity as HSL verified by inhibition properties. The HSL concentration per g tissue was several-fold higher in the mouse brown adipose tissue than in the rat white adipose tissue, but the specific activities per mg protein were similar. Cold-exposure (4 degrees C) of the mice for 24 h approximately doubled the HSL concentration but this increase parallelled the overall protein increase and did not reflect a specific effect on the HSL.

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Year:  1987        PMID： 3329536     DOI： 10.1007/bf01119481

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  7 in total

1.  Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice.

Authors:  Justin Darcy; Samuel McFadden; Yimin Fang; Joshua A Huber; Chi Zhang; Liou Y Sun; Andrzej Bartke
Journal:  Endocrinology       Date:  2016-10-14       Impact factor: 4.736

2.  Down-regulation of hormone-sensitive lipase in sterol ester-laden J774.2 macrophages.

Authors:  C A Jepson; J A Harrison; F B Kraemer; S J Yeaman
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

3.  NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo.

Authors:  Jihyun Kim; Min Sung Park; Kyoungsoo Ha; Chulhong Park; Jisu Lee; Randall L Mynatt; Ji Suk Chang
Journal:  J Lipid Res       Date:  2018-07-19       Impact factor: 5.922

4.  Identification and characterization of a supraclavicular brown adipose tissue in mice.

Authors:  Qianxing Mo; Jordan Salley; Tony Roshan; Lisa A Baer; Francis J May; Eric J Jaehnig; Adam C Lehnig; Xin Guo; Qiang Tong; Alli M Nuotio-Antar; Farnaz Shamsi; Yu-Hua Tseng; Kristin I Stanford; Miao-Hsueh Chen
Journal:  JCI Insight       Date:  2017-06-02

Review 5.  The brain and brown fat.

Authors:  Cristina Contreras; Francisco Gonzalez; Johan Fernø; Carlos Diéguez; Kamal Rahmouni; Rubén Nogueiras; Miguel López
Journal:  Ann Med       Date:  2014-06-10       Impact factor: 4.709

Review 6.  Fatty acid metabolism and the basis of brown adipose tissue function.

Authors:  María Calderon-Dominguez; Joan F Mir; Raquel Fucho; Minéia Weber; Dolors Serra; Laura Herrero
Journal:  Adipocyte       Date:  2015-12-10       Impact factor: 4.534

7.  Real-time monitoring of cAMP in brown adipocytes reveals differential compartmentation of β1 and β3-adrenoceptor signalling.

Authors:  Sukanya Arcot Kannabiran; Dominic Gosejacob; Birte Niemann; Viacheslav O Nikolaev; Alexander Pfeifer
Journal:  Mol Metab       Date:  2020-04-01       Impact factor: 7.422
  7 in total

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