Eugenio Velasco-Ortega1, Nicola Alberto Valente1,2, Giovanna Iezzi3, Morena Petrini3, Giacomo Derchi4, Antonio Barone2,4. 1. Department of Stomatology, Faculty of Dentistry, University of Seville, Seville, Spain. 2. Formerly, Unit of Oral Surgery and Implantology, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland. 3. Department of Medical, Oral and Biotechnological Science, University G. d'Annunzio of Chieti, Chieti, Italy. 4. Department of Surgical, Medical, Molecular and of the Critical Needs Pathologies, University-Hospital of Pisa, Complex Unit of Stomatology and Oral Surgery, Pisa, Italy.
Abstract
BACKGROUND:Lateral maxillary sinus augmentation (MSA) is a predictable bone regeneration technique in case of atrophy of the posterior-upper maxilla. Aimed at obtaining quantity and quality of bone suitable for receiving osseointegrated implants, its success is largely due to the skill of the surgeon, but also to the characteristics of the biomaterial used. METHODS:Twenty-four patients needing MSA were included in the study. The patients were randomly allocated to three different groups: anorganic bovine bone mineral as control, tricalcium phosphate with or without hyaluronic acid (HA) as test groups. Nine months after MSA, bone biopsies were harvested for the histomorphometric analysis. Secondary outcomes were mean bone gain, intraoperative and postoperative complications, implant insertion torque, implant failure, and patient-reported outcome measures. RESULTS: Although the percentage of new bone was not statistically different between the three groups (P = .191), the percentages of residual biomaterial was significantly higher (P < .000) and nonmineralized tissue significantly lower (P < .000) in the control than in the test groups. Test groups did not differ significantly from each other for all histomorphometric parameters. The implant insertion torque was significantly higher in the control group (P < .0005). The rest of the secondary outcomes were not significantly different between the groups. CONCLUSION:MSA is a safe and predictable procedure in terms of histological, clinical, and PROAMs, regardless of the biomaterial used. The addition of HA did not influence the outcomes.
RCT Entities:
BACKGROUND: Lateral maxillary sinus augmentation (MSA) is a predictable bone regeneration technique in case of atrophy of the posterior-upper maxilla. Aimed at obtaining quantity and quality of bone suitable for receiving osseointegrated implants, its success is largely due to the skill of the surgeon, but also to the characteristics of the biomaterial used. METHODS: Twenty-four patients needing MSA were included in the study. The patients were randomly allocated to three different groups: anorganic bovine bone mineral as control, tricalcium phosphate with or without hyaluronic acid (HA) as test groups. Nine months after MSA, bone biopsies were harvested for the histomorphometric analysis. Secondary outcomes were mean bone gain, intraoperative and postoperative complications, implant insertion torque, implant failure, and patient-reported outcome measures. RESULTS: Although the percentage of new bone was not statistically different between the three groups (P = .191), the percentages of residual biomaterial was significantly higher (P < .000) and nonmineralized tissue significantly lower (P < .000) in the control than in the test groups. Test groups did not differ significantly from each other for all histomorphometric parameters. The implant insertion torque was significantly higher in the control group (P < .0005). The rest of the secondary outcomes were not significantly different between the groups. CONCLUSION: MSA is a safe and predictable procedure in terms of histological, clinical, and PROAMs, regardless of the biomaterial used. The addition of HA did not influence the outcomes.
Authors: Eugenio Velasco-Ortega; Angela Sierra-Baztan; Alvaro Jiménez-Guerra; Antonio España-López; Iván Ortiz-Garcia; Enrique Núñez-Márquez; Jesús Moreno-Muñoz; José Luis Rondón-Romero; José López-López; Loreto Monsalve-Guil Journal: Int J Environ Res Public Health Date: 2021-09-22 Impact factor: 3.390
Authors: David T Wu; Jose G Munguia-Lopez; Ye Won Cho; Xiaolu Ma; Vivian Song; Zhiyue Zhu; Simon D Tran Journal: Molecules Date: 2021-11-22 Impact factor: 4.411
Authors: Juan Alberto Fernández-Ruiz; Mariano Sánchez-Siles; Yolanda Guerrero-Sánchez; Jesús Pato-Mourelo; Fabio Camacho-Alonso Journal: Int J Environ Res Public Health Date: 2021-03-25 Impact factor: 3.390