BACKGROUND: This two-part study explored the safety, feasibility, and efficacy of a mild-moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD). METHODS: First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12-wk in-home, remotely supervised, mild-moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured. RESULTS: Dose-escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12-wk in-home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05). CONCLUSIONS: An in-home, mild-moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.
BACKGROUND: This two-part study explored the safety, feasibility, and efficacy of a mild-moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD). METHODS: First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12-wk in-home, remotely supervised, mild-moderate intensity strengthening program in eight boys. Safety measures included T2 MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend/descend four stairs) were also measured. RESULTS: Dose-escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12-wk in-home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors P < .01; knee flexors P < .05) and function (descending steps P < .05). CONCLUSIONS: An in-home, mild-moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.
Authors: Sean C Forbes; Glenn A Walter; William D Rooney; Dah-Jyuu Wang; Soren DeVos; Jim Pollaro; William Triplett; Donovan J Lott; Rebecca J Willcocks; Claudia Senesac; Michael J Daniels; Barry J Byrne; Barry Russman; Richard S Finkel; James S Meyer; H Lee Sweeney; Krista Vandenborne Journal: Radiology Date: 2013-05-21 Impact factor: 11.105
Authors: Daniel Hind; James Parkin; Victoria Whitworth; Saleema Rex; Tracey Young; Lisa Hampson; Jennie Sheehan; Chin Maguire; Hannah Cantrill; Elaine Scott; Heather Epps; Marion Main; Michelle Geary; Heather McMurchie; Lindsey Pallant; Daniel Woods; Jennifer Freeman; Ellen Lee; Michelle Eagle; Tracey Willis; Francesco Muntoni; Peter Baxter Journal: Pilot Feasibility Stud Date: 2017-03-27
Authors: Stian Hammer; Michel Toussaint; Maria Vollsæter; Marianne Nesbjørg Tvedt; Ola Drange Røksund; Gregory Reychler; Hans Lund; Tiina Andersen Journal: J Rehabil Med Date: 2022-01-11 Impact factor: 3.959