Literature DB >> 3329411

Spleen in falciparum malaria: ultrastructural study.

E Pongponratn1, M Riganti, D Bunnag, T Harinasuta.   

Abstract

An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping of parasitized erythrocytes are commonly seen in splenic sinusoids and cords. Erythrocytes forming rosette structure around immuno-presenting cells is observed. The results of this study provide evidence that the mechanisms underlying splenic host defence in malaria include both immunological and non-immunological interaction with erythrocytes. Splenic trapping of parasitized erythrocytes is an important defence mechanism and the phagocytosis of erythrocytes probably accounts for anaemia.

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Year:  1987        PMID： 3329411

Source DB:  PubMed          Journal:  Southeast Asian J Trop Med Public Health        ISSN： 0125-1562            Impact factor:   0.267


  8 in total

1.  Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis.

Authors:  Prasad Dasari; Anja Fries; Sophia D Heber; Abdulgabar Salama; Igor-Wolfgang Blau; Klaus Lingelbach; Sebastian Chakrit Bhakdi; Rachanee Udomsangpetch; Michael Torzewski; Karina Reiss; Sucharit Bhakdi
Journal:  Med Microbiol Immunol       Date:  2014-07-02       Impact factor: 3.402

2.  Malaria-induced splenic infarction.

Authors:  Jeong-Hwan Hwang; Chang-Seop Lee
Journal:  Am J Trop Med Hyg       Date:  2014-10-06       Impact factor: 2.345

3.  Fatal Plasmodium falciparum malaria causes specific patterns of splenic architectural disorganization.

Authors:  Britta C Urban; Tran T Hien; Nicholas P Day; Nguyen H Phu; Rachel Roberts; Emsri Pongponratn; Margret Jones; Nguyen T H Mai; Delia Bethell; Gareth D H Turner; David Ferguson; Nicholas J White; David J Roberts
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

Review 4.  The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology.

Authors:  Pierre A Buffet; Innocent Safeukui; Guillaume Deplaine; Valentine Brousse; Virginie Prendki; Marc Thellier; Gareth D Turner; Odile Mercereau-Puijalon
Journal:  Blood       Date:  2010-09-17       Impact factor: 22.113

5.  TREM-1 modulation produces positive outcome on the histopathology and cytokines release profile of Plasmodium berghei-infected mice.

Authors:  Voon Kin Chin; Afiq Mohd Yusof Asyran; Zainul Amiruddin Zakaria; Wan Omar Abdullah; Pei Pei Chong; Norshariza Nordin; Zaid Osamah Ibraheem; Roslaini Abdul Majid; Rusliza Basir
Journal:  J Parasit Dis       Date:  2018-12-15

6.  SIRPα/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen.

Authors:  Javier Gordon Ogembo; Danny A Milner; Keith G Mansfield; Scott J Rodig; George F Murphy; Jeffery L Kutok; Geraldine S Pinkus; Joyce D Fingeroth
Journal:  J Immunol       Date:  2012-04-04       Impact factor: 5.422

7.  Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment.

Authors:  E Schwarzer; F Turrini; D Ulliers; G Giribaldi; H Ginsburg; P Arese
Journal:  J Exp Med       Date:  1992-10-01       Impact factor: 14.307

Review 8.  Malarial pigment hemozoin and the innate inflammatory response.

Authors:  Martin Olivier; Kristin Van Den Ham; Marina Tiemi Shio; Fikregabrail Aberra Kassa; Sophie Fougeray
Journal:  Front Immunol       Date:  2014-02-05       Impact factor: 7.561
  8 in total

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