Melissa K Thoene1, Matthew C Van Ormer2, Elizabeth R Lyden3, Maranda K Thompson2, Ana G Yuil-Valdes4, Sathish Kumar Natarajan5, Maheswari S Mukherjee6, Tara M Nordgren7, Jeremy D Furtado8, Ann L Anderson-Berry2, Corrine K Hanson9, Jessica N Snowden10. 1. Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA. melissak.thoene@unmc.edu. 2. Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68198, USA. 3. College of Public Health, University of Nebraska Medical Center, 984375 Nebraska Medical Center, Omaha, NE, 68198-4375, USA. 4. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA. 5. Department of Nutrition & Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, UK. 6. Cytotechnology Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, 68198, USA. 7. Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, USA. 8. Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA, 02215, USA. 9. Medical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, 68198, USA. 10. Pediatric Infectious Disease, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Abstract
BACKGROUND: Perinatal inflammation adversely affects health. Therefore, aims of this IRB-approved study are: (1) compare inflammatory compounds within and between maternal and umbilical cord blood samples at the time of delivery, (2) assess relationships between inflammatory compounds in maternal and cord blood with birth characteristics/outcomes, and (3) assess relationships between blood and placental fat-soluble nutrients with blood levels of individual inflammatory compounds. METHODS: Mother-infant dyads were enrolled (n = 152) for collection of birth data and biological samples of maternal blood, umbilical cord blood, and placental tissue. Nutrient levels included: lutein + zeaxanthin; lycopene; α-, β-carotene; β-cryptoxanthin; retinol; α-, γ-, δ-tocopherol. Inflammatory compounds included: tumor necrosis factor-α, superoxide dismutase, interleukins (IL) 1β, 2, 6, 8, 10. RESULTS: Median inflammatory compound levels were 1.2-2.3 times higher in cord vs. maternal blood, except IL2 (1.3 times lower). Multiple significant correlations existed between maternal vs. infant inflammatory compounds (range of r = 0.22-0.48). While relationships existed with blood nutrient levels, the most significant were identified in placenta where all nutrients (except δ-tocopherol) exhibited relationships with inflammatory compounds. Relationships between anti-inflammatory nutrients and proinflammatory compounds were primarily inverse. CONCLUSION: Inflammation is strongly correlated between mother-infant dyads. Fat-soluble nutrients have relationships with inflammatory compounds, suggesting nutrition is a modifiable factor. IMPACT: Mother and newborn inflammation status are strongly interrelated. Levels of fat-soluble nutrients in blood, but especially placenta, are associated with blood levels of proinflammatory and anti-inflammatory compounds in both mother and newborn infant. As fat-soluble nutrient levels are associated with blood inflammatory compounds, nutrition is a modifiable factor to modulate inflammation and improve perinatal outcomes.
BACKGROUND: Perinatal inflammation adversely affects health. Therefore, aims of this IRB-approved study are: (1) compare inflammatory compounds within and between maternal and umbilical cord blood samples at the time of delivery, (2) assess relationships between inflammatory compounds in maternal and cord blood with birth characteristics/outcomes, and (3) assess relationships between blood and placental fat-soluble nutrients with blood levels of individual inflammatory compounds. METHODS: Mother-infant dyads were enrolled (n = 152) for collection of birth data and biological samples of maternal blood, umbilical cord blood, and placental tissue. Nutrient levels included: lutein + zeaxanthin; lycopene; α-, β-carotene; β-cryptoxanthin; retinol; α-, γ-, δ-tocopherol. Inflammatory compounds included: tumor necrosis factor-α, superoxide dismutase, interleukins (IL) 1β, 2, 6, 8, 10. RESULTS: Median inflammatory compound levels were 1.2-2.3 times higher in cord vs. maternal blood, except IL2 (1.3 times lower). Multiple significant correlations existed between maternal vs. infant inflammatory compounds (range of r = 0.22-0.48). While relationships existed with blood nutrient levels, the most significant were identified in placenta where all nutrients (except δ-tocopherol) exhibited relationships with inflammatory compounds. Relationships between anti-inflammatory nutrients and proinflammatory compounds were primarily inverse. CONCLUSION: Inflammation is strongly correlated between mother-infant dyads. Fat-soluble nutrients have relationships with inflammatory compounds, suggesting nutrition is a modifiable factor. IMPACT: Mother and newborn inflammation status are strongly interrelated. Levels of fat-soluble nutrients in blood, but especially placenta, are associated with blood levels of proinflammatory and anti-inflammatory compounds in both mother and newborn infant. As fat-soluble nutrient levels are associated with blood inflammatory compounds, nutrition is a modifiable factor to modulate inflammation and improve perinatal outcomes.
Authors: Jessica Rose; Rachel Vassar; Katelyn Cahill-Rowley; Susan R Hintz; David K Stevenson Journal: Am J Perinatol Date: 2015-07-24 Impact factor: 1.862
Authors: Ye Ji Shim; Byung Yoon Choi; Kyo Hoon Park; Hyunju Lee; Young Mi Jung; Yu Mi Kim Journal: Mediators Inflamm Date: 2018-09-19 Impact factor: 4.711