Literature DB >> 33293155

A bio-degradable synthetic membrane to treat superficial and deep second degree burn wounds in adults and children - 4 year experience.

S A Blome-Eberwein1, H Amani2, D D Lozano2, C Gogal2, D Boorse2, P Pagella2.   

Abstract

INTRODUCTION: A new bio-degradable synthetic membrane was recently introduced to treat second degree burns in adults and pediatric patients.
OBJECTIVE: To assess complications and outcomes using this absorbable synthetic membrane to treat second degree burns.
METHODS: 229 burn patients, 138 pediatric, with superficial and deep second -degree wounds, treated with the absorbable synthetic membrane (Suprathel®, Polymedics, Denkendorf, Germany) were included in this study. Patients were treated under anesthesia or moderate sedation. The wound bed was prepared by using either rough debridement or dermabrasion excision. After hemostasis, the membrane was applied to the wound with an outer layer dressing of fatty gauze, bridal veil, absorptive gauze and an ACE® wrap. The outer dressing was removed every one to four days, depending on exudate, in order to closely follow the wound through the translucent membrane and fatty gauze layers. After complete epithelialization, the dressing separated and could be removed. The study focused on the need for subsequent grafting, healing time, patient pain level, hypertrophic scarring and rate of infection.
RESULTS: All wounds in this study that were treated with Suprathel® healed without grafting. The average TBSA (Total Body Surface Area) was 8.9% (1%-60%). Average time to healing was 13.7 days for ≥ 90% epithelialization with 11.9 days for pediatric patients versus 14.7 days for adults. Throughout the treatment period, the average pain level was 1.9 on a 10-point scale. 27 patients developed hypertrophic scarring in some areas (11.7%). Average Length of stay (LOS) was 6.9 days. The rate of infection was 3.8% (8/229). Failure or progression to full thickness in part of the wounds was 5.2% (12/229).
CONCLUSION: In treating second degree burn wounds, this membrane provides a simple, effective solution alternative with good outcomes and less pain than conventional and previously studied treatment options in the same institution. Fewer dressing changes and easier overall management of the wounds contribute to its favorable profile.
Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.

Entities:  

Keywords:  Absorbable membrane; Outcome; Pain; Pediatric; Second degree burns; Skin substitute; Suprathel®

Year:  2020        PMID: 33293155     DOI: 10.1016/j.burns.2020.08.008

Source DB:  PubMed          Journal:  Burns        ISSN: 0305-4179            Impact factor:   2.744


  4 in total

Review 1.  Made in Germany: A Quality Indicator Not Only in the Automobile Industry But Also When It Comes to Skin Replacement: How an Automobile Textile Research Institute Developed a New Skin Substitute.

Authors:  Herbert Leopold Haller; Matthias Rapp; Daniel Popp; Sebastian Philipp Nischwitz; Lars Peter Kamolz
Journal:  Medicina (Kaunas)       Date:  2021-02-05       Impact factor: 2.430

Review 2.  Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review.

Authors:  Herbert L Haller; Sigrid E Blome-Eberwein; Ludwik K Branski; Joshua S Carson; Roselle E Crombie; William L Hickerson; Lars Peter Kamolz; Booker T King; Sebastian P Nischwitz; Daniel Popp; Jeffrey W Shupp; Steven E Wolf
Journal:  Medicina (Kaunas)       Date:  2021-04-30       Impact factor: 2.430

3.  Effect of precise partial scab removal on the repair of deep partial-thickness burn wounds in children: a retrospective study.

Authors:  Yunfei Chi; Huinan Yin; Xin Chen; Quan Hu; Wei Liu; Li Feng; Jiake Chai
Journal:  Transl Pediatr       Date:  2021-11

Review 4.  Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies.

Authors:  Alissa Olga Lukomskyj; Nikitha Rao; Lei Yan; Jasmine Sarah Pye; Haiyan Li; Bin Wang; Jiao Jiao Li
Journal:  Stem Cell Rev Rep       Date:  2022-02-12       Impact factor: 6.692

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.