K Ye1, M Chen2, J Li1, Q Zhu1, Y Lu1, H Yuan3. 1. Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China. 2. Department of Radiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium. 3. Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China. Electronic address: huishy@bjmu.edu.cn.
Abstract
AIM: To evaluate the accuracy of ultra-low-dose computed tomography (ULDCT) with ASiR-V using a noise index (SmartmA) for pulmonary nodule detection and Lung CT Screening Reporting And Data System (Lung-RADS) classifications compared with low-dose CT (LDCT). MATERIALS AND METHODS: Two-hundred and ten patients referred for lung cancer screening underwent conventional chest LDCT (0.80 ± 0.28 mSv) followed immediately by ULDCT (0.16 ± 0.03 mSv). ULDCT was scanned using 120 kV/SmartmA with a noise index of 28 HU and reconstructed with ASiR-V70%. The types and diameters of all nodules were recorded. The attenuation of pure ground-glass nodules (pGGNs) was measured on LDCT. All nodules were further classified using Lung-RADS. Sensitivities of nodule detection on ULDCT were analysed using LDCT as the reference standard. Logistic regression was used to establish a prediction model for the sensitivity of nodules. RESULTS: LDCT revealed 362 nodules and the overall sensitivity on ULDCT was 90.1%. The sensitivity for solid nodules (SNs) of ≥1 mm diameter was 96.6% (228/236) and 100% (26/26) for SNs of ≥6 mm diameter. For pGGNs of ≥6 mm, the overall sensitivity was 93% (40/43) and 100% (29/29) for nodules with a attenuation value -700 HU or more. The agreement of Lung-RADS classification between two scans was good. On logistic regression, diameter was the only independent predictor for sensitivity of SNs (p<0.05). Diameter and attenuation value were predictors for pGGNs (p<0.05). CONCLUSION: ULDCT with ASiR-V using SmartmA is suitable for lung-cancer screening in people with a BMI ≤35 kg/m2 as it has a low radiation dose of 0.16 mSv, high sensitivity for nodule detection and good performance of Lung-RADS classifications.
AIM: To evaluate the accuracy of ultra-low-dose computed tomography (ULDCT) with ASiR-V using a noise index (SmartmA) for pulmonary nodule detection and Lung CT Screening Reporting And Data System (Lung-RADS) classifications compared with low-dose CT (LDCT). MATERIALS AND METHODS: Two-hundred and ten patients referred for lung cancer screening underwent conventional chest LDCT (0.80 ± 0.28 mSv) followed immediately by ULDCT (0.16 ± 0.03 mSv). ULDCT was scanned using 120 kV/SmartmA with a noise index of 28 HU and reconstructed with ASiR-V70%. The types and diameters of all nodules were recorded. The attenuation of pure ground-glass nodules (pGGNs) was measured on LDCT. All nodules were further classified using Lung-RADS. Sensitivities of nodule detection on ULDCT were analysed using LDCT as the reference standard. Logistic regression was used to establish a prediction model for the sensitivity of nodules. RESULTS: LDCT revealed 362 nodules and the overall sensitivity on ULDCT was 90.1%. The sensitivity for solid nodules (SNs) of ≥1 mm diameter was 96.6% (228/236) and 100% (26/26) for SNs of ≥6 mm diameter. For pGGNs of ≥6 mm, the overall sensitivity was 93% (40/43) and 100% (29/29) for nodules with a attenuation value -700 HU or more. The agreement of Lung-RADS classification between two scans was good. On logistic regression, diameter was the only independent predictor for sensitivity of SNs (p<0.05). Diameter and attenuation value were predictors for pGGNs (p<0.05). CONCLUSION: ULDCT with ASiR-V using SmartmA is suitable for lung-cancer screening in people with a BMI ≤35 kg/m2 as it has a low radiation dose of 0.16 mSv, high sensitivity for nodule detection and good performance of Lung-RADS classifications.