Triptish Bhatia1, Swathi Gujral2, Vikas Sharma3, Nupur Kumari4, Joel Wood5, Maribeth A Wesesky5, Jacquelynn Jones5, Louanne W Davis6, Satish Iyenger7, Gretchen L Haas2,5, Vishwajit L Nimgaonkar5,8,9, Smita N Deshpande10. 1. Indo-USA Projects and NCU-ICMR, Department of Psychiatry and De-addiction, Centre of Excellence in Mental Health, ABVIMS. -Dr. R.M.L. Hospital, New Delhi, India. 2. VA VISN 4 Mental Illness Research, Education, and Clinical Center of Excellence (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. 3. NCU-ICMR, Department of Psychiatry and De-addiction, Centre of Excellence in Mental Health, ABVIMS. -Dr.R.M.L. Hospital, New Delhi, India. 4. SATYAM-DST Project, Department of Psychiatry and De-addiction, Centre of Excellence in Mental Health, ABVIMS. -Dr.R.M.L. Hospital, New Delhi, India. 5. Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 6. Department of Research, Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis, IN, USA. 7. Department of Statistics, University of Pittsburgh, Pittsburgh, PA, USA. 8. Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, USA. 9. Behavioral Health Service Line, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. 10. Department of Psychiatry and De-addiction, Centre of Excellence in Mental Health, ABVIMS. -Dr.R.M.L. Hospital, New Delhi, India.
Abstract
OBJECTIVE: The aim of this study was to identify factors associated with acceptability and efficacy of yoga training (YT) for improving cognitive dysfunction in individuals with schizophrenia (SZ). METHODS: We analysed data from two published clinical trials of YT for cognitive dysfunction among Indians with SZ: (1) a 21-day randomised controlled trial (RCT, N = 286), 3 and 6 months follow-up and (2) a 21-day open trial (n = 62). Multivariate analyses were conducted to examine the association of baseline characteristics (age, sex, socio-economic status, educational status, duration, and severity of illness) with improvement in cognition (i.e. attention and face memory) following YT. Factors associated with acceptability were identified by comparing baseline demographic variables between screened and enrolled participants as well as completers versus non-completers. RESULTS: Enrolled participants were younger than screened persons who declined participation (t = 2.952, p = 0.003). No other characteristics were associated with study enrollment or completion. Regarding efficacy, schooling duration was nominally associated with greater and sustained cognitive improvement on a measure of facial memory. No other baseline characteristics were associated with efficacy of YT in the open trial, the RCT, or the combined samples (n = 148). CONCLUSIONS: YT is acceptable even among younger individuals with SZ. It also enhances specific cognitive functions, regardless of individual differences in selected psychosocial characteristics. Thus, yoga could be incorporated as adjunctive therapy for patients with SZ. Importantly, our results suggest cognitive dysfunction is remediable in persons with SZ across the age spectrum.
RCT Entities:
OBJECTIVE: The aim of this study was to identify factors associated with acceptability and efficacy of yoga training (YT) for improving cognitive dysfunction in individuals with schizophrenia (SZ). METHODS: We analysed data from two published clinical trials of YT for cognitive dysfunction among Indians with SZ: (1) a 21-day randomised controlled trial (RCT, N = 286), 3 and 6 months follow-up and (2) a 21-day open trial (n = 62). Multivariate analyses were conducted to examine the association of baseline characteristics (age, sex, socio-economic status, educational status, duration, and severity of illness) with improvement in cognition (i.e. attention and face memory) following YT. Factors associated with acceptability were identified by comparing baseline demographic variables between screened and enrolled participants as well as completers versus non-completers. RESULTS: Enrolled participants were younger than screened persons who declined participation (t = 2.952, p = 0.003). No other characteristics were associated with study enrollment or completion. Regarding efficacy, schooling duration was nominally associated with greater and sustained cognitive improvement on a measure of facial memory. No other baseline characteristics were associated with efficacy of YT in the open trial, the RCT, or the combined samples (n = 148). CONCLUSIONS: YT is acceptable even among younger individuals with SZ. It also enhances specific cognitive functions, regardless of individual differences in selected psychosocial characteristics. Thus, yoga could be incorporated as adjunctive therapy for patients with SZ. Importantly, our results suggest cognitive dysfunction is remediable in persons with SZ across the age spectrum.
Entities:
Keywords:
attention; cognition; face memory; schizophrenia; yoga
Authors: R C Gur; J D Ragland; P J Moberg; W B Bilker; C Kohler; S J Siegel; R E Gur Journal: Neuropsychopharmacology Date: 2001-11 Impact factor: 7.853
Authors: N Jayaram; S Varambally; R V Behere; G Venkatasubramanian; R Arasappa; R Christopher; B N Gangadhar Journal: Indian J Psychiatry Date: 2013-07 Impact factor: 1.759