Literature DB >> 33291655

Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views.

Moon Jong Kim1, Yuanjian Huang1, Jae-Il Park1,2,3.   

Abstract

Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.

Entities:  

Keywords:  Wnt signaling; cancer; gastrointestinal cancers; molecular targeting; therapeutic targeting of Wnt signaling; β-catenin; β-catenin paradox

Year:  2020        PMID： 33291655      PMCID： PMC7761926          DOI： 10.3390/cancers12123638

Source DB:  PubMed          Journal:  Cancers (Basel)        ISSN： 2072-6694            Impact factor:   6.639


  170 in total

1.  Wise, a context-dependent activator and inhibitor of Wnt signalling.

Authors:  Nobue Itasaki; C Michael Jones; Sara Mercurio; Alison Rowe; Pedro M Domingos; James C Smith; Robb Krumlauf
Journal:  Development       Date:  2003-09       Impact factor: 6.868

Review 2.  Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology.

Authors:  Jacquelyn O Russell; Satdarshan P Monga
Journal:  Annu Rev Pathol       Date:  2017-11-10       Impact factor: 23.472

3.  Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Authors:  Bon-Kyoung Koo; Maureen Spit; Ingrid Jordens; Teck Y Low; Daniel E Stange; Marc van de Wetering; Johan H van Es; Shabaz Mohammed; Albert J R Heck; Madelon M Maurice; Hans Clevers
Journal:  Nature       Date:  2012-08-30       Impact factor: 49.962

4.  APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression.

Authors:  Klaus-Peter Janssen; Paola Alberici; Hafida Fsihi; Claudia Gaspar; Cor Breukel; Patrick Franken; Christophe Rosty; Miguel Abal; Fatima El Marjou; Ron Smits; Daniel Louvard; Riccardo Fodde; Sylvie Robine
Journal:  Gastroenterology       Date:  2006-08-16       Impact factor: 22.682

5.  An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

Authors:  Foster C Gonsalves; Keren Klein; Brittany B Carson; Shauna Katz; Laura A Ekas; Steve Evans; Robert Nagourney; Timothy Cardozo; Anthony M C Brown; Ramanuj DasGupta
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-10       Impact factor: 11.205

6.  EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells.

Authors:  J Huang; D Xiao; G Li; J Ma; P Chen; W Yuan; F Hou; J Ge; M Zhong; Y Tang; X Xia; Z Chen
Journal:  Oncogene       Date:  2013-06-10       Impact factor: 9.867

7.  USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.

Authors:  Pingping Hou; Xingdi Ma; Qiang Zhang; Chang-Jiun Wu; Wenting Liao; Jun Li; Huamin Wang; Jun Zhao; Xin Zhou; Carolyn Guan; Jeffery Ackroyd; Shan Jiang; Jianhua Zhang; Denise J Spring; Y Alan Wang; Ronald A DePinho
Journal:  Genes Dev       Date:  2019-09-05       Impact factor: 11.361

Review 8.  Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex.

Authors:  Youn-Sang Jung; Jae-Il Park
Journal:  Exp Mol Med       Date:  2020-02-10       Impact factor: 8.718

9.  Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1-mutated or IDH2-mutated solid tumours.

Authors:  Remco J Molenaar; Robert J S Coelen; Mohammed Khurshed; Eva Roos; Matthan W A Caan; Myra E van Linde; Mathilde Kouwenhoven; Jos A M Bramer; Judith V M G Bovée; Ron A Mathôt; Heinz-Josef Klümpen; Hanneke W M van Laarhoven; Cornelis J F van Noorden; W Peter Vandertop; Hans Gelderblom; Thomas M van Gulik; Johanna W Wilmink
Journal:  BMJ Open       Date:  2017-06-10       Impact factor: 3.006

10.  Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

Authors:  Radu M Suciu; Armand B Cognetta; Zachary E Potter; Benjamin F Cravatt
Journal:  ACS Med Chem Lett       Date:  2018-05-26       Impact factor: 4.345
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  7 in total

1.  Pharmacologic Manipulation of Late SV40 Factor Suppresses Wnt Signaling and Inhibits Growth of Allogeneic and Syngeneic Colon Cancer Xenografts.

Authors:  Saran Lotfollahzadeh; Dominic Lo; Emily A York; Marc A Napoleon; Wenqing Yin; Nagla Elzinad; John Le; Mengwei Zhang; Xiaosheng Yang; Austin Morrissey; Murad Elsadawi; Qing Zhao; Scott E Schaus; Ulla Hansen; Vipul C Chitalia
Journal:  Am J Pathol       Date:  2022-06-13       Impact factor: 5.770

2.  Anti-tumor activity of a recombinant soluble Fzd7 decoy receptor in human gastric and colon cancer cells.

Authors:  Nasim Hafezi; Reza Valadan; Omran-Hossein Asgarian; Abolghasem Ajami
Journal:  Iran J Basic Med Sci       Date:  2022-02       Impact factor: 2.532

Review 3.  Targeting Wnt/β-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents.

Authors:  Federico Selvaggi; Teresa Catalano; Roberto Cotellese; Gitana Maria Aceto
Journal:  Cancers (Basel)       Date:  2022-04-10       Impact factor: 6.575

Review 4.  Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum.

Authors:  Jose Francisco Islas; Adriana G Quiroz-Reyes; Paulina Delgado-Gonzalez; Hector Franco-Villarreal; Juan Luis Delgado-Gallegos; Elsa N Garza-Treviño; Carlos A Gonzalez-Villarreal
Journal:  Cancers (Basel)       Date:  2022-08-16       Impact factor: 6.575

5.  WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cells in vitro.

Authors:  Xiaonan Zhang; Berthold Schalke; Krisztian Kvell; Katharina Kriegsmann; Mark Kriegsmann; Thomas Graeter; Gerhard Preissler; German Ott; Katrin Kurz; Elena Bulut; Philipp Ströbel; Alexander Marx; Djeda Belharazem
Journal:  Front Oncol       Date:  2022-07-29       Impact factor: 5.738

Review 6.  Targeting Wnt Signaling in Endometrial Cancer.

Authors:  Iram Fatima; Susmita Barman; Rajani Rai; Kristina W W Thiel; Vishal Chandra
Journal:  Cancers (Basel)       Date:  2021-05-13       Impact factor: 6.639

7.  Adenomatous polyposis coli in cancer and therapeutic implications.

Authors:  Olivia Noe; Louis Filipiak; Rachel Royfman; Austin Campbell; Leslie Lin; Danae Hamouda; Laura Stanbery; John Nemunaitis
Journal:  Oncol Rev       Date:  2021-06-24
  7 in total

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