Literature DB >> 33291619

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 Treated with Tocilizumab.

Carmen Niño-Taravilla1,2, Yazmín P Espinosa-Vielma3, Hugo Otaola-Arca4, Cecilia Poli-Harlowe3,5, Lorena I Tapia6,7, Paula Ortiz-Fritz1.   

Abstract

We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis. After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run to determine the best treatment.

Entities:  

Keywords:  MIS-C; PIMS-TS; SARS-COV-2; Tocilizumab

Year:  2020        PMID: 33291619      PMCID: PMC7768469          DOI: 10.3390/pediatric12030029

Source DB:  PubMed          Journal:  Pediatr Rep        ISSN: 2036-749X


  19 in total

1.  Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City.

Authors:  Shubhi Kaushik; Scott I Aydin; Kim R Derespina; Prerna B Bansal; Shanna Kowalsky; Rebecca Trachtman; Jennifer K Gillen; Michelle M Perez; Sara H Soshnick; Edward E Conway; Asher Bercow; Howard S Seiden; Robert H Pass; Henry M Ushay; George Ofori-Amanfo; Shivanand S Medar
Journal:  J Pediatr       Date:  2020-06-14       Impact factor: 4.406

Review 2.  Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management.

Authors:  Natasha A Nakra; Dean A Blumberg; Angel Herrera-Guerra; Satyan Lakshminrusimha
Journal:  Children (Basel)       Date:  2020-07-01

3.  Hyperinflammatory shock in children during COVID-19 pandemic.

Authors:  Shelley Riphagen; Xabier Gomez; Carmen Gonzalez-Martinez; Nick Wilkinson; Paraskevi Theocharis
Journal:  Lancet       Date:  2020-05-07       Impact factor: 79.321

Review 4.  Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.

Authors:  Mehmet Soy; Gökhan Keser; Pamir Atagündüz; Fehmi Tabak; Işık Atagündüz; Servet Kayhan
Journal:  Clin Rheumatol       Date:  2020-05-30       Impact factor: 2.980

Review 5.  Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Brescia, Italy.

Authors:  Paola Toniati; Simone Piva; Marco Cattalini; Emirena Garrafa; Francesca Regola; Francesco Castelli; Franco Franceschini; Paolo Airò; Chiara Bazzani; Eva-Andrea Beindorf; Marialma Berlendis; Michela Bezzi; Nicola Bossini; Maurizio Castellano; Sergio Cattaneo; Ilaria Cavazzana; Giovanni-Battista Contessi; Massimo Crippa; Andrea Delbarba; Elena De Peri; Angela Faletti; Matteo Filippini; Matteo Filippini; Micol Frassi; Mario Gaggiotti; Roberto Gorla; Michael Lanspa; Silvia Lorenzotti; Rosa Marino; Roberto Maroldi; Marco Metra; Alberto Matteelli; Denise Modina; Giovanni Moioli; Giovanni Montani; Maria-Lorenza Muiesan; Silvia Odolini; Elena Peli; Silvia Pesenti; Maria-Chiara Pezzoli; Ilenia Pirola; Alessandro Pozzi; Alessandro Proto; Francesco-Antonio Rasulo; Giulia Renisi; Chiara Ricci; Damiano Rizzoni; Giuseppe Romanelli; Mara Rossi; Massimo Salvetti; Francesco Scolari; Liana Signorini; Marco Taglietti; Gabriele Tomasoni; Lina-Rachele Tomasoni; Fabio Turla; Alberto Valsecchi; Davide Zani; Francesco Zuccalà; Fiammetta Zunica; Emanuele Focà; Laura Andreoli; Nicola Latronico
Journal:  Autoimmun Rev       Date:  2020-05-03       Impact factor: 9.754

6.  An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study.

Authors:  Lucio Verdoni; Angelo Mazza; Annalisa Gervasoni; Laura Martelli; Maurizio Ruggeri; Matteo Ciuffreda; Ezio Bonanomi; Lorenzo D'Antiga
Journal:  Lancet       Date:  2020-05-13       Impact factor: 79.321

Review 7.  Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

Authors:  Bingwen Liu; Min Li; Zhiguang Zhou; Xuan Guan; Yufei Xiang
Journal:  J Autoimmun       Date:  2020-04-10       Impact factor: 7.094

8.  Why tocilizumab could be an effective treatment for severe COVID-19?

Authors:  Binqing Fu; Xiaoling Xu; Haiming Wei
Journal:  J Transl Med       Date:  2020-04-14       Impact factor: 5.531

9.  Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality.

Authors:  Chi Zhang; Zhao Wu; Jia-Wen Li; Hong Zhao; Gui-Qiang Wang
Journal:  Int J Antimicrob Agents       Date:  2020-03-29       Impact factor: 5.283

10.  Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.

Authors:  Elizabeth Whittaker; Alasdair Bamford; Julia Kenny; Myrsini Kaforou; Christine E Jones; Priyen Shah; Padmanabhan Ramnarayan; Alain Fraisse; Owen Miller; Patrick Davies; Filip Kucera; Joe Brierley; Marilyn McDougall; Michael Carter; Adriana Tremoulet; Chisato Shimizu; Jethro Herberg; Jane C Burns; Hermione Lyall; Michael Levin
Journal:  JAMA       Date:  2020-07-21       Impact factor: 157.335

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  4 in total

1.  Recent research on the application of biologics in the treatment of multisystem inflammatory syndrome in children after SARS-CoV-2 infection.

Authors:  Han-Yu Cui; Chang-Ping Hu
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2022-02-15

2.  International Survey on Severe Acute Respiratory Syndrome Coronavirus 2 and Acute Pancreatitis Co-occurrence in Children.

Authors:  Mordechai Slae; Michael Wilschanski; Elvi Sanjines; Maisam Abu-El-Haija; Zachary M Sellers
Journal:  Pancreas       Date:  2021-10-01       Impact factor: 3.243

Review 3.  Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6.

Authors:  L Lacina; J Brábek; Š Fingerhutová; J Zeman; K Smetana
Journal:  Physiol Res       Date:  2021-04-30       Impact factor: 1.881

4.  Critical analysis of acute kidney injury in pediatric COVID-19 patients in the intensive care unit.

Authors:  Rupesh Raina; Ronith Chakraborty; Isabelle Mawby; Nirav Agarwal; Sidharth Sethi; Michael Forbes
Journal:  Pediatr Nephrol       Date:  2021-04-29       Impact factor: 3.714

  4 in total

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