Tobias Hengartner1, Mark Adams2, Riccardo E Pfister3, Diane Snyers4, Jane McDougall5, Salome Waldvogel6, Katrin Held-Egli7, Lea Spring8, Bjarte Rogdo9, Thomas Riedel10, Romaine Arlettaz Mieth2. 1. Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland, tobias.hengartner@uzh.ch. 2. Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland. 3. Department of Child and Adolescent, University Hospital Geneva, Geneva, Switzerland. 4. Department of Neonatology, University Hospital Lausanne, Lausanne, Switzerland. 5. Department of Neonatology, University Hospital Berne, Berne, Switzerland. 6. Department of Neonatology, University of Basel Children's Hospital, Basel, Switzerland. 7. Department of Neonatology, Children's Clinic, Cantonal Hospital Aarau, Aarau, Switzerland. 8. Department of Neonatology, Children's Hospital of Lucerne, Lucerne, Switzerland. 9. Neonatal and Paediatric Intensive Care Unit, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland. 10. Paediatric and Neonatal Intensive Care Unit, Department of Paediatrics, Cantonal Hospital Graubuenden, Chur, Switzerland.
Abstract
AIM: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. METHODS: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). RESULTS: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020-1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566-3.998) numbers were associated with ROP development. CONCLUSIONS: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.
AIM: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. METHODS: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). RESULTS: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020-1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566-3.998) numbers were associated with ROP development. CONCLUSIONS: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.
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