Literature DB >> 33291074

Dihydromyricetin promotes longevity and activates the transcription factors FOXO and AOP in Drosophila.

Xiaolan Fan1,2, Yao Zeng1, Ziqiang Fan1, Liang Cui1, Wenhao Song1, Qi Wu1, Yue Gao1, Deying Yang1,2, Xueping Mao1,2, Bo Zeng1,2, Mingwang Zhang1,2, Qingyong Ni1,2, Yan Li1,2, Tao Wang1,2, Diyan Li1,2, Mingyao Yang1,2.   

Abstract

Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.

Entities:  

Keywords:  AKT; Dihydromyricetin; ERK; FOXO; anti-aging

Mesh：

Substances：

Year:  2020        PMID： 33291074      PMCID： PMC7835053          DOI： 10.18632/aging.202156

Source DB:  PubMed          Journal:  Aging (Albany NY)        ISSN： 1945-4589            Impact factor:   5.682


  52 in total

Review 1.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis.

Authors:  Lance W Peterson; David Artis
Journal:  Nat Rev Immunol       Date:  2014-03       Impact factor: 53.106

Review 2.  The roles of FoxOs in modulation of aging by calorie restriction.

Authors:  Dae Hyun Kim; Min Hi Park; Eun Kyeong Lee; Yeon Ja Choi; Ki Wung Chung; Kyoung Mi Moon; Min Jo Kim; Hye Jin An; June Whoun Park; Nam Deuk Kim; Byung Pal Yu; Hae Young Chung
Journal:  Biogerontology       Date:  2014-08-22       Impact factor: 4.277

3.  Dihydromyricetin reverses MRP2-mediated MDR and enhances anticancer activity induced by oxaliplatin in colorectal cancer cells.

Authors:  Ziyuan Wang; Xiaoting Sun; Yuanyuan Feng; Xuan Liu; Lihong Zhou; Hua Sui; Qing Ji; Qiukai E; Jia Chen; Lili Wu; Qi Li
Journal:  Anticancer Drugs       Date:  2017-03       Impact factor: 2.248

4.  Dihydromyricetin induces mitochondria-mediated apoptosis in HepG2 cells through down-regulation of the Akt/Bad pathway.

Authors:  Zhuangwei Zhang; Huiqin Zhang; Shiyong Chen; Yan Xu; Anjun Yao; Qi Liao; Liyuan Han; Zuquan Zou; Xiaohong Zhang
Journal:  Nutr Res       Date:  2017-01-17       Impact factor: 3.315

5.  Caloric restriction delays disease onset and mortality in rhesus monkeys.

Authors:  Ricki J Colman; Rozalyn M Anderson; Sterling C Johnson; Erik K Kastman; Kristopher J Kosmatka; T Mark Beasley; David B Allison; Christina Cruzen; Heather A Simmons; Joseph W Kemnitz; Richard Weindruch
Journal:  Science       Date:  2009-07-10       Impact factor: 47.728

Review 6.  Role of insulin-like signalling in Drosophila lifespan.

Authors:  Maria E Giannakou; Linda Partridge
Journal:  Trends Biochem Sci       Date:  2007-04-06       Impact factor: 13.807

Review 7.  The hallmarks of aging.

Authors:  Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

8.  Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy.

Authors:  Yongbiao Chen; Lizhi Lv; Huifeng Pi; Weijia Qin; Jianwei Chen; Dengfang Guo; Jianyu Lin; Xiaobing Chi; Zhelong Jiang; Hejun Yang; Yi Jiang
Journal:  Oncotarget       Date:  2016-11-22

9.  Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Authors:  Colin Selman; Steven Lingard; Agharul I Choudhury; Rachel L Batterham; Marc Claret; Melanie Clements; Faruk Ramadani; Klaus Okkenhaug; Eugene Schuster; Eric Blanc; Matthew D Piper; Hind Al-Qassab; John R Speakman; Danielle Carmignac; Iain C A Robinson; Janet M Thornton; David Gems; Linda Partridge; Dominic J Withers
Journal:  FASEB J       Date:  2007-10-10       Impact factor: 5.191

Review 10.  Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Authors:  Rute Martins; Gordon J Lithgow; Wolfgang Link
Journal:  Aging Cell       Date:  2015-12-08       Impact factor: 9.304
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  3 in total

Review 1.  Flavonoids-Natural Gifts to Promote Health and Longevity.

Authors:  Xiaolan Fan; Ziqiang Fan; Ziyue Yang; Tiantian Huang; Yingdong Tong; Deying Yang; Xueping Mao; Mingyao Yang
Journal:  Int J Mol Sci       Date:  2022-02-16       Impact factor: 5.923

Review 2.  The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.

Authors:  Angelica Varesi; Salvatore Chirumbolo; Lucrezia Irene Maria Campagnoli; Elisa Pierella; Gaia Bavestrello Piccini; Adelaide Carrara; Giovanni Ricevuti; Catia Scassellati; Cristian Bonvicini; Alessia Pascale
Journal:  Antioxidants (Basel)       Date:  2022-06-22

Review 3.  Molecular inhibition of RAS signalling to target ageing and age-related health.

Authors:  Mihails Laskovs; Linda Partridge; Cathy Slack
Journal:  Dis Model Mech       Date:  2022-09-16       Impact factor: 5.732
  3 in total

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