Jennifer L LaBarre1,2, Carolyn F McCabe2, Tamara R Jones3, Peter Xk Song4, Steven E Domino5, Marjorie C Treadwell5, Dana C Dolinoy2,3, Vasantha Padmanabhan3,5,6, Charles F Burant1, Jaclyn M Goodrich3. 1. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. 2. Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. 3. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. 4. Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. 5. Department of Obstetrics & Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA. 6. Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
Abstract
Aim: To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Materials & methods: Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. Results: M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. Conclusion: The maternal lipidome may be influential in establishing the infant epigenome.
Aim: To classify the association between the maternal lipidome and DNA methylation in cord blood leukocytes. Materials & methods: Untargeted lipidomics was performed on first trimester maternal plasma (M1) and delivery maternal plasma (M3) in 100 mothers from the Michigan Mother-Infant Pairs cohort. Cord blood leukocyte DNA methylation was profiled using the Infinium EPIC bead array and empirical Bayes modeling identified differential DNA methylation related to maternal lipid groups. Results:M3-saturated lysophosphatidylcholine was associated with 45 differentially methylated loci and M3-saturated lysophosphatidylethanolamine was associated with 18 differentially methylated loci. Biological pathways enriched among differentially methylated loci by M3 saturated lysophosphatidylcholines were related to cell proliferation and growth. Conclusion: The maternal lipidome may be influential in establishing the infant epigenome.
Entities:
Keywords:
DNA methylation; developmental epigenetics; epigenome-wide association studies; lipidomics; lysophospholipids; pregnancy; umbilical cord blood
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