Dirk Rades1, Jaspar Witteler2, Jan Leppert3, Steven E Schild4. 1. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany; dirk.rades@uksh.de. 2. Department of Radiation Oncology, University of Lübeck, Lübeck, Germany. 3. Department of Neurosurgery, University of Lübeck, Lübeck, Germany. 4. Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
Abstract
BACKGROUND/AIM: Patients requiring re-irradiation for recurrent glioblastoma multiforme (GBM) may benefit from individualized therapy. This study aimed to identify predictors of survival and contribute to treatment personalization. PATIENTS AND METHODS: In 28 patients with recurrent GBM, nine factors were analyzed for associations with survival: Main location and type of recurrence, Karnofsky performance score (KPS), age, gender, interval between primary radiotherapy and recurrence, gross total resection (GTR), equivalent dose in 2-Gy fractions (EQD2) of re-irradiation and cumulative EQD2 of primary and re-irradiation. RESULTS: On univariate analyses, GTR (p=0.047), EQD2 ≥30 Gy (p=0.029) and cumulative EQD2 ≥90 Gy (p=0.023) were significantly associated with better survival; frontal location (p=0.119) and KPS 80-100% (p=0.067) showed trends. In multivariate analyses, frontal location (p=0.032) and cumulative EQD2 ≥90 Gy (p=0.038) were significant; KPS 80-100% (p=0.110) and EQD2 ≥30 Gy (p=0.083) showed trends. CONCLUSION: Predictors of survival after re-irradiation for recurrent GBM were identified that can help when designing personalized treatments. Use of irradiation with EQD2 ≥30 Gy appeared superior to lower doses.
BACKGROUND/AIM: Patients requiring re-irradiation for recurrent glioblastoma multiforme (GBM) may benefit from individualized therapy. This study aimed to identify predictors of survival and contribute to treatment personalization. PATIENTS AND METHODS: In 28 patients with recurrent GBM, nine factors were analyzed for associations with survival: Main location and type of recurrence, Karnofsky performance score (KPS), age, gender, interval between primary radiotherapy and recurrence, gross total resection (GTR), equivalent dose in 2-Gy fractions (EQD2) of re-irradiation and cumulative EQD2 of primary and re-irradiation. RESULTS: On univariate analyses, GTR (p=0.047), EQD2 ≥30 Gy (p=0.029) and cumulative EQD2 ≥90 Gy (p=0.023) were significantly associated with better survival; frontal location (p=0.119) and KPS 80-100% (p=0.067) showed trends. In multivariate analyses, frontal location (p=0.032) and cumulative EQD2 ≥90 Gy (p=0.038) were significant; KPS 80-100% (p=0.110) and EQD2 ≥30 Gy (p=0.083) showed trends. CONCLUSION: Predictors of survival after re-irradiation for recurrent GBM were identified that can help when designing personalized treatments. Use of irradiation with EQD2 ≥30 Gy appeared superior to lower doses.
Authors: Svenja Kopelke; Troels W Kjaer; Soeren Tvilsted; Steven E Schild; Tobias Bartscht; Dirk Rades Journal: In Vivo Date: 2022 Jan-Feb Impact factor: 2.155
Authors: Lucio De Maria; Lodovico Terzi di Bergamo; Alfredo Conti; Kazuhiko Hayashi; Valentina Pinzi; Taro Murai; Rachelle Lanciano; Sigita Burneikiene; Michela Buglione di Monale; Stefano Maria Magrini; Marco Maria Fontanella Journal: Front Oncol Date: 2021-03-29 Impact factor: 6.244