Bernardino Clavo1,2,3,4,5, Elizabeth Córdoba-Lanús6,7,8, Francisco Rodríguez-Esparragón1, Sara E Cazorla-Rivero6,7,8,9, Omar García-Pérez6,7,8,9, José E Piñero6,8,9, Jesús Villar1,10, Angeles Blanco11, Cristina Torres-Ascensión1,2, José L Martín-Barrasa1,12, Jesús M González-Martin1, Pedro Serrano-Aguilar4,13,14, Jacob Lorenzo-Morales6,8,9. 1. Research Unit, Hospital Universitario Dr. Negrín, 35019 Las Palmas de Gran Canaria, Spain. 2. Chronic Pain Unit, Hospital Universitario Dr. Negrín, 35019 Las Palmas de Gran Canaria, Spain. 3. Radiation Oncology Department, Hospital Universitario Dr. Negrín, 35019 Las Palmas de Gran Canaria, Spain. 4. RETIC de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. 5. Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), BioPharm Group, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain. 6. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, La Laguna, 38200 Tenerife, Spain. 7. Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, La Laguna, 38200 Tenerife, Spain. 8. Red Cooperativa de Enfermedades Tropicales (RICET), Instituto de Salud Carlos III, 28029 Madrid, Spain. 9. Departamento de Obstetricia, Ginecología, Pediatría, Medicina Preventiva y Salud Pública, Toxicología, Medicina Legal y Forense y Parasitología, Universidad de La Laguna, La Laguna, 38200 Tenerife, Spain. 10. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain. 11. Chemical Engineering & Materials Department, Universidad Complutense, 28040 Madrid, Spain. 12. Animal Infectious Diseases and Ictiopathology, Universitary Institute of Animal Health and Food Safety (IUSA), Universidad de Las Palmas de Gran Canaria, 35413 Arucas, Spain. 13. Servicio de Evaluación y Planificación del Servicio Canario de Salud (SESCS), 38109 Santa Cruz de Tenerife, Spain. 14. Red de Agencias de Evaluación de Tecnologías Sanitarias y Prestaciones del Sistema Nacional de Salud (RedETS), 28071 Madrid, Spain.
Abstract
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing profound health, economic, and social problems worldwide. Management of personal protective equipment (PPE) and its potential limited availability have created concerns about the increased risks for healthcare professionals at hospitals and nursing homes. Ozone is a powerful oxidant agent. The objectives of this study were to examine the effects of ozone treatment on PPE contaminated with SARS-CoV-2, and to explore whether relative humidity could modify those effects. METHODS: PPE contaminated by heat-inactivated SARS-CoV-2 were treated with different ozone concentrations, exposure times, and relative humidity conditions. SARS-CoV-2 gene amplification was assessed by real-time polymerase chain reaction. RESULTS: There was no amplification of SARS-CoV-2 in PPE after the following ozone exposures: 30 s at 10,000 ppm (20 g/m3), 5 min at 4000 ppm, and 10 min at 2000 ppm. At lower ozone concentrations, 4-12 ppm (0.008-0.024 g/m3), the effects were highly dependent on the relative humidity conditions. CONCLUSIONS: Oxidative stress induced by ozone exposure eliminated heat-inactivated SARS-CoV-2 in different PPE components under appropriate exposure times, ozone concentrations, and relative humidity conditions. These findings could have implications in decreasing the risk of contamination associated with personal protective equipment management and in increasing its availability. Further research in the original SARS-CoV-2 strain is guaranteed.
BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing profound health, economic, and social problems worldwide. Management of personal protective equipment (PPE) and its potential limited availability have created concerns about the increased risks for healthcare professionals at hospitals and nursing homes. Ozone is a powerful oxidant agent. The objectives of this study were to examine the effects of ozone treatment on PPE contaminated with SARS-CoV-2, and to explore whether relative humidity could modify those effects. METHODS: PPE contaminated by heat-inactivated SARS-CoV-2 were treated with different ozone concentrations, exposure times, and relative humidity conditions. SARS-CoV-2 gene amplification was assessed by real-time polymerase chain reaction. RESULTS: There was no amplification of SARS-CoV-2 in PPE after the following ozone exposures: 30 s at 10,000 ppm (20 g/m3), 5 min at 4000 ppm, and 10 min at 2000 ppm. At lower ozone concentrations, 4-12 ppm (0.008-0.024 g/m3), the effects were highly dependent on the relative humidity conditions. CONCLUSIONS: Oxidative stress induced by ozone exposure eliminated heat-inactivated SARS-CoV-2 in different PPE components under appropriate exposure times, ozone concentrations, and relative humidity conditions. These findings could have implications in decreasing the risk of contamination associated with personal protective equipment management and in increasing its availability. Further research in the original SARS-CoV-2 strain is guaranteed.
Entities:
Keywords:
COVID-19; SARS-CoV-2; decontamination; oxidative stress; ozone treatment; personal protective equipment; reactive oxygen species
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Authors: Elizabeth Córdoba-Lanús; Omar García-Pérez; Francisco Rodríguez-Esparragón; Carlos J Bethencourt-Estrella; Laura B Torres-Mata; Angeles Blanco; Jesús Villar; Oscar Sanz; Juan J Díaz; José L Martín-Barrasa; Pedro Serrano-Aguilar; José-Enrique Piñero; Bernardino Clavo; Jacob Lorenzo-Morales Journal: PLoS One Date: 2022-07-22 Impact factor: 3.752
Authors: Laura B Torres-Mata; Omar García-Pérez; Francisco Rodríguez-Esparragón; Angeles Blanco; Jesús Villar; Fernando Ruiz-Apodaca; José L Martín-Barrasa; Jesús M González-Martín; Pedro Serrano-Aguilar; José E Piñero; Elizabeth Córdoba-Lanús; Jacob Lorenzo-Morales; Bernardino Clavo Journal: Int J Environ Res Public Health Date: 2022-07-16 Impact factor: 4.614