Yi Ji1, Siyuan Chen2, Kaiying Yang3, Bo Xiang3, Xian Jiang4, Xuewen Xu5, Lizhi Li6, Tong Qiu3, Jiangyuan Zhou3, Shiyi Dai3, Xuepeng Zhang7, Guoyan Lu8, Feiteng Kong9, Gang Yang10, Qingxia Qiu11. 1. Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China. Electronic address: jijiyuanyuan@163.com. 2. Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address: siy_chen@163.com. 3. Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China. 4. Department of Dermatology, West China Hospital of Sichuan University, Chengdu, China. 5. Department of Burns and Plastic Surgery, West China Hospital of Sichuan University, Chengdu, China. 6. Department of Pediatric Surgery, Fujian Provincial Hospital, Fuzhou, China. 7. Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. 8. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. 9. Department of Pediatric Surgery, Sichuan Women and Children's Hospital, Chengdu, China. 10. Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China; Department of Pediatric Surgery, Chengdu Shangjin Nanfu Hospital, Chengdu, China. 11. Department of Pediatric Surgery, Chengdu Shangjin Nanfu Hospital, Chengdu, China.
Abstract
BACKGROUND: Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs). OBJECTIVES: The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH. METHODS: We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited. RESULTS: In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955). LIMITATIONS: This was an uncontrolled study. CONCLUSIONS: Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.
BACKGROUND: Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs). OBJECTIVES: The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH. METHODS: We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited. RESULTS: In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955). LIMITATIONS: This was an uncontrolled study. CONCLUSIONS: Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.