Cristofer Ruiz-Gonzalez1, Pablo Roman2, Lola Rueda-Ruzafa3, Miguel Rodriguez-Arrastia4, Diana Cardona5. 1. Department of Nursing Science, Physiotherapy and Medicine, University of Almería, Ctra. Sacramento s/n, La Cañada, 04120 Almería, Spain. 2. Department of Nursing Science, Physiotherapy and Medicine, University of Almería, Ctra. Sacramento s/n, La Cañada, 04120 Almería, Spain; Health Research Center, University of Almería, Spain; Health Sciences Research Group (CTS-451), University of Almería, Spain. Electronic address: pablo.roman@ual.es. 3. Laboratory of Neuroscience, CINBIO, University of Vigo, Campus Lagoas-Marcosende, 36310 Vigo, Spain. 4. Faculty of Health Sciences, Pre-Department of Nursing, Jaume I University, 12071 Castello de la Plana, Spain; Research Group CYS, Faculty of Health Sciences, Jaume I University, 12071 Castello de la Plana, Spain. 5. Department of Nursing Science, Physiotherapy and Medicine, University of Almería, Ctra. Sacramento s/n, La Cañada, 04120 Almería, Spain; Health Research Center, University of Almería, Spain.
Abstract
BACKGROUND: Dementia is a chronic syndrome characterized by cognitive and behavioral symptoms, which may include short-term memory impairment and problems related to orientation, language, attention and perception. Although cognitive impairment (CI) is increasingly considered the main geriatric condition predisposing to dementia, its early management could still promote symptomatic relief and delay disease progression. Recently, probiotics treatment has been studied as a potential new therapeutic approach to attenuate dementia-related decline and mild cognitive impairment (MCI). Therefore, we conducted a systematic review and meta-analysis to review and analyse the available evidence on the effect of probiotics on MCI and dementia. METHODS: A systematic search and meta-analysis were performed on Cochrane Library, ProQuest, Web of Science, PubMed-Medline, The Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, ScienceDirect and Open Grey. Search terms included diagnoses of interest (dementia and MCI) and the intervention of interest (probiotic, lactobacillus and bifidobacterium). Original articles reporting the use of probiotics supplementation for the treatment of dementia and MCI were screened and studied independently by two researchers. After that, a random and fixed effects model was used at the meta-analysis stage of the results to determine its effect size. RESULTS: A total of 16 articles (10 preclinical and 6 clinical) that met the inclusion criteria for the systematic review, and 15 articles (10 preclinical and 5 clinical) for meta-analysis were finally included. In humans, the administration of probiotics improved general cognitive function after the treatment period. Similarly, an improvement in memory and spatial/non-spatial learning was identified in the probiotic group of animals compared to the control group. On the other hand, the results showed an increase in the levels of the brain-derived neurotrophic factor, an improvement in the inflammatory profile and regulation of cellular biomarkers after probiotics administration. CONCLUSION: Probiotics supplementation could be an adequate therapeutic strategy both in dementia and CI based on clinical and preclinical evidence. However, it is therefore important to translate preclinical data into clinical data where the evidence is more limited.
BACKGROUND: Dementia is a chronic syndrome characterized by cognitive and behavioral symptoms, which may include short-term memory impairment and problems related to orientation, language, attention and perception. Although cognitive impairment (CI) is increasingly considered the main geriatric condition predisposing to dementia, its early management could still promote symptomatic relief and delay disease progression. Recently, probiotics treatment has been studied as a potential new therapeutic approach to attenuate dementia-related decline and mild cognitive impairment (MCI). Therefore, we conducted a systematic review and meta-analysis to review and analyse the available evidence on the effect of probiotics on MCI and dementia. METHODS: A systematic search and meta-analysis were performed on Cochrane Library, ProQuest, Web of Science, PubMed-Medline, The Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, ScienceDirect and Open Grey. Search terms included diagnoses of interest (dementia and MCI) and the intervention of interest (probiotic, lactobacillus and bifidobacterium). Original articles reporting the use of probiotics supplementation for the treatment of dementia and MCI were screened and studied independently by two researchers. After that, a random and fixed effects model was used at the meta-analysis stage of the results to determine its effect size. RESULTS: A total of 16 articles (10 preclinical and 6 clinical) that met the inclusion criteria for the systematic review, and 15 articles (10 preclinical and 5 clinical) for meta-analysis were finally included. In humans, the administration of probiotics improved general cognitive function after the treatment period. Similarly, an improvement in memory and spatial/non-spatial learning was identified in the probiotic group of animals compared to the control group. On the other hand, the results showed an increase in the levels of the brain-derived neurotrophic factor, an improvement in the inflammatory profile and regulation of cellular biomarkers after probiotics administration. CONCLUSION: Probiotics supplementation could be an adequate therapeutic strategy both in dementia and CI based on clinical and preclinical evidence. However, it is therefore important to translate preclinical data into clinical data where the evidence is more limited.
Authors: Diana Cardona; Pablo Roman; Fernando Cañadas; Nuria Sánchez-Labraca Journal: Int J Environ Res Public Health Date: 2021-03-29 Impact factor: 3.390