Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Influence of rosmarinic acid on opsonization and intracellular killing of Escherichia coli and Staphylococcus aureus by porcine and human polymorphonuclear leucocytes.

Literature DB >> 3328496

Influence of rosmarinic acid on opsonization and intracellular killing of Escherichia coli and Staphylococcus aureus by porcine and human polymorphonuclear leucocytes.

A M Verweij-van Vught¹, B J Appelmelk, A B Groeneveld, M Sparrius, L G Thijs, D M MacLaren.

Abstract

The influence of rosmarinic acid on the function of porcine and human polymorphonuclear leucocytes was tested. Rosmarinic acid inhibited the chemiluminescence of PMNL, induced by preopsonized Zymosan or phorbol myristate acetate. The killing of Escherichia coli was inhibited by rosmarinic acid at a concentration of 2 mM, but not that of Staphylococcus aureus. The inhibition of the killing was due to an impaired opsonization, caused by an adverse influence of rosmarinic acid on complement activation. Direct effects of rosmarinic acid on the killing mechanisms of PMNL were not observed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1987 PMID： 3328496 DOI： 10.1007/bf02009058

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

Keyword Cloud
References

11 in total

1. Oxygen-dependent microbial killing by phagocytes (first of two parts).

Authors: B M Babior
Journal: N Engl J Med Date: 1978-03-23 Impact factor: 91.245

2. Regulation of the macrophage oxidative burst by mediators: effects of inhibitors.

Authors: M J Parnham; W Englberger
Journal: Agents Actions Date: 1985-03

3. Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity.

Authors: R C Allen; R L Stjernholm; R H Steele
Journal: Biochem Biophys Res Commun Date: 1972-05-26 Impact factor: 3.575

9. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid.

Authors: H Bult; A G Herman; M Rampart
Journal: Br J Pharmacol Date: 1985-02 Impact factor: 8.739

10. Role of peripheral pooling in porcine Escherichia coli sepsis.

Authors: G J Teule; A von Lingen; M A Verwey von Vught; A D Kester; R C Mackaay; P D Bezemer; G A Heidenal; L G Thijs
Journal: Circ Shock Date: 1984

Influence of rosmarinic acid on opsonization and intracellular killing of Escherichia coli and Staphylococcus aureus by porcine and human polymorphonuclear leucocytes.

1. Oxygen-dependent microbial killing by phagocytes (first of two parts).

2. Regulation of the macrophage oxidative burst by mediators: effects of inhibitors.

3. Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity.

4. Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid.

5. Rosmarinic acid inhibits external oxidative effects of human polymorphonuclear granulocytes.

6. Killing capacity of human polymorphonuclear leukocytes in aerobic and anaerobic conditions.

Review 7. The effects of oxygen radicals on pulmonary edema formation.

Review 8. Pharmacological manipulation of complement system.

9. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid.

10. Role of peripheral pooling in porcine Escherichia coli sepsis.