Literature DB >> 33280577

rRNA Methylation and Antibiotic Resistance.

I A Osterman1,2, O A Dontsova1,2,3, P V Sergiev4,2,5.   

Abstract

Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekeeping enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekeeping enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

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Year:  2020        PMID： 33280577     DOI： 10.1134/S000629792011005X

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  6 in total

1.  Identification of Differentially Expressed Genes in Nocardia brasiliensis Induced by Progesterone and Dihydrotestosterone Using Differential Display PCR.

Authors:  Claudia C Paredes-Amaya; Patricia Manzano-Gayosso; Francisca Hernández-Hernández
Journal:  Curr Microbiol       Date:  2022-10-06       Impact factor: 2.343

Review 2.  16S rRNA Methyltransferases as Novel Drug Targets Against Tuberculosis.

Authors:  M R Salaikumaran; Veena P Badiger; V L S Prasad Burra
Journal:  Protein J       Date:  2022-02-03       Impact factor: 2.371

3.  Metagenomic Insights Into the Changes of Antibiotic Resistance and Pathogenicity Factor Pools Upon Thermophilic Composting of Human Excreta.

Authors:  Katharina A Werner; Dominik Schneider; Anja Poehlein; Nina Diederich; Lara Feyen; Katharina Axtmann; Tobias Hübner; Nicolas Brüggemann; Katharina Prost; Rolf Daniel; Elisabeth Grohmann
Journal:  Front Microbiol       Date:  2022-03-31       Impact factor: 5.640

4.  50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.

Authors:  Zane T Laughlin; Suparno Nandi; Debayan Dey; Natalia Zelinskaya; Marta A Witek; Pooja Srinivas; Ha An Nguyen; Emily G Kuiper; Lindsay R Comstock; Christine M Dunham; Graeme L Conn
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-31       Impact factor: 12.779

Review 5.  Can intracellular Staphylococcus aureus in osteomyelitis be treated using current antibiotics? A systematic review and narrative synthesis.

Authors:  Anja R Zelmer; Renjy Nelson; Katharina Richter; Gerald J Atkins
Journal:  Bone Res       Date:  2022-08-12       Impact factor: 13.362

6.  RNA Expression Analysis of Mycobacterial Methyltransferases Genes in Different Resistant Strains of Mycobacterium tuberculosis.

Authors:  Samira Tarashi; Mohammad Saber Zamani; Golnaz Bahramali; Andrea Fuso; Farzam Vaziri; Morteza Karimipoor; Abolfazl Fateh; Seyed Davar Siadat
Journal:  Iran Biomed J       Date:  2022-05-01
  6 in total

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