Yusuke Suzuki1, Mikio Sakakibara2, Nariaki Shiraishi3, Hitoshi Komiya4, Masahiro Akishita5, Masafumi Kuzuya6. 1. Center for Community Liaison and Patient Consultations, Nagoya University Hospital, Nagoya, Japan, yus@med.nagoya-u.ac.jp. 2. Sugi Pharmacy Co., Ltd., Obu, Japan. 3. Department of Rehabilitation, Faculty of Health Sciences, Nihon Fukushi University, Nihon, Japan. 4. Center for Community Liaison and Patient Consultations, Nagoya University Hospital, Nagoya, Japan. 5. Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 6. Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Abstract
AIMS: As the number of older people with dementia increases, safe pharmacotherapy in this population has attracted attention in recent years. The aims of this study were to clarify the prescribing patterns in older patients who were prescribed anti-dementia drugs and to investigate the association of potentially inappropriate medications (PIMs) with the use of anti-dementia drugs. METHODS: Adults aged ≥65 years, who were prescribed anti-dementia drugs at 585 pharmacies across Japan (N = 7,953), were surveyed. The percentage of prescriptions of anti-dementia drugs and the effect of those prescriptions on PIMs were investigated. RESULTS: Prescriptions of anti-dementia drugs were found in 4.4% of the entire study population. A multiple logistic regression analysis revealed that the use of anti-dementia drugs reduced the risk of prescribing psychotropic drugs, which represented PIMs, and that a combination of anti-dementia drugs (e.g., cholineesterase inhibitor with memantine) may reduce the risk of prescribing PIMs compared with monotherapy. CONCLUSION: The use of anti-dementia drugs was associated with fewer prescriptions of drugs considered as PIMs. The Author(s). Published by S. Karger AG, Basel.
AIMS: As the number of older people with dementia increases, safe pharmacotherapy in this population has attracted attention in recent years. The aims of this study were to clarify the prescribing patterns in older patients who were prescribed anti-dementia drugs and to investigate the association of potentially inappropriate medications (PIMs) with the use of anti-dementia drugs. METHODS: Adults aged ≥65 years, who were prescribed anti-dementia drugs at 585 pharmacies across Japan (N = 7,953), were surveyed. The percentage of prescriptions of anti-dementia drugs and the effect of those prescriptions on PIMs were investigated. RESULTS: Prescriptions of anti-dementia drugs were found in 4.4% of the entire study population. A multiple logistic regression analysis revealed that the use of anti-dementia drugs reduced the risk of prescribing psychotropic drugs, which represented PIMs, and that a combination of anti-dementia drugs (e.g., cholineesterase inhibitor with memantine) may reduce the risk of prescribing PIMs compared with monotherapy. CONCLUSION: The use of anti-dementia drugs was associated with fewer prescriptions of drugs considered as PIMs. The Author(s). Published by S. Karger AG, Basel.
Authors: Matthew P Gray; Gabrielle Dziuba; Karen Quach; Adrian Wong; Pamela L Smithburger; Amy L Seybert; Sandra L Kane-Gill Journal: Am J Geriatr Psychiatry Date: 2018-09-27 Impact factor: 4.105
Authors: Mary Butler; Victoria A Nelson; Heather Davila; Edward Ratner; Howard A Fink; Laura S Hemmy; J Riley McCarten; Terry R Barclay; Michelle Brasure; Robert L Kane Journal: Ann Intern Med Date: 2017-12-19 Impact factor: 25.391