Literature DB >> 33279650

miRNA biomarkers for predicting overall survival outcomes for head and neck squamous cell carcinoma.

Zeng-Hong Wu1, Yi Zhong2, Tao Zhou3, Hong-Jun Xiao4.   

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor of the upper aerodigestive tract. The loss and gain of miRNA function promote cancer development through various mechanisms. RNA sequencing (RNA-seq) and miRNAs sequencing data from the Cancer Genome Atlas (TCGA) was used to show the dysfunctional miRNAs microenvironment and to provide useful biomarkers for miRNAs therapy. Seven miRNAs were found to be independent prognostic factors of HNSCC patients in the training cohort. A total of 60 target genes for these miRNAs were predicted. Nine target genes (CDCA4, CXCL14, FLNC, KLF7, NBEAL2, P4HA1, PFKM, PFN2 and SEPPINE1) were correlated with patient's overall survival (OS) outcomes. We identified novel miRNAs markers for the prognosis of head and neck squamous cell carcinoma.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Head and neck squamous cell carcinoma; Prognosis; TCGA; miRNAs

Mesh：

Substances：

Year:  2020        PMID： 33279650     DOI： 10.1016/j.ygeno.2020.12.002

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  9 in total

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