Kehinde S Okunade1,2, Olusola F Olowoselu3, Sarah John-Olabode3, Basirat O Hassan4, Oluwatosin J Akinsola5, Chidinma M Nwogu2, Aloy O Ugwu2, Olusanjo E Moses6, Kabiru A Rabiu6, Adegbenga Ajepe2, Muisi A Adenekan2, Adebola A Adejimi5, Sulaimon A Akanmu3, Phyllis J Kanki7. 1. Department of Obstetrics and Gynecology, College of Medicine, University of Lagos, Lagos, Nigeria. 2. Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria. 3. Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria. 4. AIDS Prevention Initiative in Nigeria (APIN) Clinic, Lagos University Teaching Hospital, Lagos, Nigeria. 5. Department of Community Health and Primary Health Care, College of Medicine, University of Lagos, Lagos, Nigeria. 6. Department of Obstetrics and Gynecology, Lagos State University Teaching Hospital, Ikeja, Nigeria. 7. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA.
Abstract
OBJECTIVE: To examine the effects of selenium supplementation on pregnancy outcomes and disease progression among HIV-infected pregnant women in Lagos. METHODS: A randomized, placebo-controlled trial conducted among HIV-positive pregnant women between September 2018 and August 2019. At enrollment, 90 women were randomly assigned into each treatment arm to receive either a daily tablet of 200 μg elemental selenium or a placebo. Relevant participants' sociodemographic and clinical data were collected at enrollment and delivery. RESULTS: Women in the selenium arm had a significantly lower risk of preterm delivery (relative risk [RR] 0.32, 95% confidence interval [CI] 0.11-0.96) and a non-significant reduction in the risk of delivering term neonates with a low delivery weight (RR 0.24, 95% CI 0.05-1.19). Supplemental selenium does not increase the risk of perinatal death and adverse drug events. CONCLUSION: The study reported a beneficial effect of prenatal selenium supplements on the risk of preterm delivery with no further reduction in risk among HIV-infected women who used the supplements for more than 14 weeks. TRIAL REGISTRATION: Pan African Clinical Trial Registry (PACTR201809756724274).
OBJECTIVE: To examine the effects of selenium supplementation on pregnancy outcomes and disease progression among HIV-infected pregnant women in Lagos. METHODS: A randomized, placebo-controlled trial conducted among HIV-positive pregnant women between September 2018 and August 2019. At enrollment, 90 women were randomly assigned into each treatment arm to receive either a daily tablet of 200 μg elemental selenium or a placebo. Relevant participants' sociodemographic and clinical data were collected at enrollment and delivery. RESULTS: Women in the selenium arm had a significantly lower risk of preterm delivery (relative risk [RR] 0.32, 95% confidence interval [CI] 0.11-0.96) and a non-significant reduction in the risk of delivering term neonates with a low delivery weight (RR 0.24, 95% CI 0.05-1.19). Supplemental selenium does not increase the risk of perinatal death and adverse drug events. CONCLUSION: The study reported a beneficial effect of prenatal selenium supplements on the risk of preterm delivery with no further reduction in risk among HIV-infected women who used the supplements for more than 14 weeks. TRIAL REGISTRATION: Pan African Clinical Trial Registry (PACTR201809756724274).
Authors: Kehinde S Okunade; Olusola F Olowoselu; Gbemisola E Osanyin; Sarah John-Olabode; Sulaimon A Akanmu; Rose I Anorlu Journal: Int J Gynaecol Obstet Date: 2018-04-23 Impact factor: 3.561
Authors: F Tara; M P Rayman; H Boskabadi; M Ghayour-Mobarhan; A Sahebkar; O Yazarlu; S Ouladan; S Tavallaie; M Azimi-Nezhad; M T Shakeri; M S Teymoori; B S Razavi; M Oladi; G Ferns Journal: J Obstet Gynaecol Date: 2010-01 Impact factor: 1.246
Authors: Roland Kupka; Gernard I Msamanga; Donna Spiegelman; Steve Morris; Ferdinand Mugusi; David J Hunter; Wafaie W Fawzi Journal: J Nutr Date: 2004-10 Impact factor: 4.798
Authors: Roland Kupka; Ferdinand Mugusi; Said Aboud; Gernard I Msamanga; Julia L Finkelstein; Donna Spiegelman; Wafaie W Fawzi Journal: Am J Clin Nutr Date: 2008-06 Impact factor: 7.045