Jori O Ruuskanen1, Ville Kytö2,3,4, Jussi P Posti5, Päivi Rautava6,7, Jussi O T Sipilä1,8. 1. Neurocenter, Department of Neurology, Clinical Neurosciences (J.O.R., J.O.T.S.), University of Turku, Finland. 2. Center for Population Health Research (V.K.), University of Turku, Finland. 3. Turku University Hospital, Research Center of Applied and Preventive Cardiovascular Medicine (V.K.), University of Turku, Finland. 4. Heart Center, Turku University Hospital, Finland (V.K.). 5. Neurocenter, Department of Neurosurgery, Turku Brain Injury Centre (J.P.P.), University of Turku, Finland. 6. Department of Public Health (P.R.), University of Turku, Finland. 7. Turku Clinical Research Centre, Turku University Hospital, Finland (P.R.). 8. Siun Sote, North Karelia Central Hospital, Department of Neurology, Joensuu, Finland (J.O.T.S.).
Abstract
BACKGROUND AND PURPOSE: Epidemiology of cerebral venous thrombosis (CVT) has been reported to be changing. Because long-term nationwide data are needed to confirm this, we studied CVT occurrence between 2005 and 2014 in Finland. METHODS: All acute CVT admissions were retrieved from a mandatory registry covering mainland Finland. Patients aged ≥18 years were included. One admission per patient was allowed. RESULTS: We identified 563 patients with CVT (56.5% women). Overall incidence was 1.32/100 000 (95% CI, 1.21-1.43) per year with a 5.0% annual increase. In people <55 years of age, incidence was 0.92/100 000 (0.76-1.10) for men and 1.65/100 000 (1.43-1.89) for women, whereas for those 55 years or older incidence was 1.61 (1.34-1.91) for men and 1.17 (0.96-1.41) for women. In-hospital mortality was 2.1% with no sex difference. One-year mortality was 7.9%. Long-term mortality was higher in men (adjusted hazard ratio, 1.61 [1.09-2.38]) and in older patients (1.95 [1.69-2.24]; per 10-year increment). CONCLUSIONS: Overall incidence of CVT in Finland was similar to that reported in the Netherlands and in Australia. There was a 5.0% yearly increase in the rate of admissions while in-hospital mortality was low. Sex-specific incidence rates differed markedly between younger and older people. Long-term mortality increased with age and was higher in men.
BACKGROUND AND PURPOSE: Epidemiology of cerebral venous thrombosis (CVT) has been reported to be changing. Because long-term nationwide data are needed to confirm this, we studied CVT occurrence between 2005 and 2014 in Finland. METHODS: All acute CVT admissions were retrieved from a mandatory registry covering mainland Finland. Patients aged ≥18 years were included. One admission per patient was allowed. RESULTS: We identified 563 patients with CVT (56.5% women). Overall incidence was 1.32/100 000 (95% CI, 1.21-1.43) per year with a 5.0% annual increase. In people <55 years of age, incidence was 0.92/100 000 (0.76-1.10) for men and 1.65/100 000 (1.43-1.89) for women, whereas for those 55 years or older incidence was 1.61 (1.34-1.91) for men and 1.17 (0.96-1.41) for women. In-hospital mortality was 2.1% with no sex difference. One-year mortality was 7.9%. Long-term mortality was higher in men (adjusted hazard ratio, 1.61 [1.09-2.38]) and in older patients (1.95 [1.69-2.24]; per 10-year increment). CONCLUSIONS: Overall incidence of CVT in Finland was similar to that reported in the Netherlands and in Australia. There was a 5.0% yearly increase in the rate of admissions while in-hospital mortality was low. Sex-specific incidence rates differed markedly between younger and older people. Long-term mortality increased with age and was higher in men.
Authors: Sharifa Nasreen; Andrew J Calzavara; Maria E Sundaram; Shannon E MacDonald; Christiaan H Righolt; Menaka Pai; Thalia S Field; Lily W Zhou; Sarah E Wilson; Jeffrey C Kwong Journal: BMJ Open Date: 2021-12-17 Impact factor: 2.692
Authors: Jussi O T Sipilä; Jori O Ruuskanen; Eetu Heervä; Jussi P Posti; Päivi Rautava; Ville Kytö Journal: Stroke Date: 2022-04-05 Impact factor: 7.914
Authors: Jörg B Schulz; Peter Berlit; Hans-Christoph Diener; Christian Gerloff; Andreas Greinacher; Christine Klein; Gabor C Petzold; Marco Piccininni; Sven Poli; Rainer Röhrig; Helmuth Steinmetz; Thomas Thiele; Tobias Kurth Journal: Ann Neurol Date: 2021-08-23 Impact factor: 11.274