Dorthe C Pedersen1, Lise G Bjerregaard1, Kathleen M Rasmussen2, Ellen A Nohr3, Jennifer L Baker4. 1. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark. 2. Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA. 3. Research Unit of Obstetrics and Gynecology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. 4. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark. Electronic address: Jennifer.Lyn.Baker@regionh.dk.
Abstract
AIMS: We examined whether a woman's birthweight, childhood height, body mass index (BMI), and BMI changes from childhood to pregnancy were associated with risks of gestational diabetes mellitus (GDM). METHODS: We studied 13,031 women from the Copenhagen School Health Records Register born 1959-1996 with birthweight and measured anthropometric information at ages 7 and/or 13. The diagnosis of GDM (n = 255) was obtained from a national health register. Risk ratios (RR) were estimated using log-linear binomial regression. RESULTS: Own birthweight and childhood height were inversely associated with GDM. Girls with overweight at age 7 had a higher risk of GDM than girls with normal-weight (RR: 1.79, 95% CI: 1.31, 2.47). Compared to women with normal-weight in childhood and adulthood, risks of GDM were higher in women who developed overweight from age 7 to pregnancy (RR: 4.62; 3.48, 6.14) or had overweight at both times (RR: 4.71; 3.24, 6.85). In women whose BMI normalized from age 7 to pregnancy the RR for GDM was 1.08 (0.47, 2.46). CONCLUSIONS: Lower birthweight, shorter childhood height, and higher childhood BMI are associated with increased risks of GDM. Efforts to help girls maintain a normal BMI before pregnancy may be warranted to minimize risks of GDM.
AIMS: We examined whether a woman's birthweight, childhood height, body mass index (BMI), and BMI changes from childhood to pregnancy were associated with risks of gestational diabetes mellitus (GDM). METHODS: We studied 13,031 women from the Copenhagen School Health Records Register born 1959-1996 with birthweight and measured anthropometric information at ages 7 and/or 13. The diagnosis of GDM (n = 255) was obtained from a national health register. Risk ratios (RR) were estimated using log-linear binomial regression. RESULTS: Own birthweight and childhood height were inversely associated with GDM. Girls with overweight at age 7 had a higher risk of GDM than girls with normal-weight (RR: 1.79, 95% CI: 1.31, 2.47). Compared to women with normal-weight in childhood and adulthood, risks of GDM were higher in women who developed overweight from age 7 to pregnancy (RR: 4.62; 3.48, 6.14) or had overweight at both times (RR: 4.71; 3.24, 6.85). In women whose BMI normalized from age 7 to pregnancy the RR for GDM was 1.08 (0.47, 2.46). CONCLUSIONS: Lower birthweight, shorter childhood height, and higher childhood BMI are associated with increased risks of GDM. Efforts to help girls maintain a normal BMI before pregnancy may be warranted to minimize risks of GDM.
Authors: Nirmin F Juber; Abdishakur Abdulle; Abdulla AlJunaibi; Abdulla AlNaeemi; Amar Ahmad; Andrea Leinberger-Jabari; Ayesha S Al Dhaheri; Eiman AlZaabi; Fatima Mezhal; Fatma Al-Maskari; Fatme AlAnouti; Habiba Alsafar; Juma Alkaabi; Laila Abdel Wareth; Mai Aljaber; Marina Kazim; Michael Weitzman; Mohammad Al-Houqani; Mohammed Hag Ali; Naima Oumeziane; Omar El-Shahawy; Scott Sherman; Sharifa AlBlooshi; Syed M Shah; Tom Loney; Wael Almahmeed; Youssef Idaghdour; Raghib Ali Journal: Int J Environ Res Public Health Date: 2022-08-19 Impact factor: 4.614