THE MAIN CAUSES OF THE COMPLICATED COURSE OF COVID-19 IN PATIENTS WITH DIABETES MELLITUS AND TREATMENT (REVIEW).

Among the main risk factors for the development of a severe course of Coronavirus disease 2019 (COVID-19) are old age, arterial hypertension, diabetes mellitus (DM), chronic obstructive pulmonary diseases, cardiovascular and cerebrovascular diseases. The aim of this study was determinating the main causes of complicated COVID-19 course in diabetic patients. Publications were searched using PubMed and Google Scholar for keywords: COVID-19, diabetes, hyperglycemia, carbohydrate metabolism disorders, and complications. The review of scientific literature considers the main causes and pathogenetic mechanisms of COVID-19 complications development in patients with DM. Groups of factors that worsen the disease course were identified. We also proved that modern treatment of COVID-19 in diabetic patients should consider all risk factors and include a multidisciplinary team approach with specialists in emergency medicine, endocrinology, infectious diseases, respiratory support, nutrition and rehabilitation. The main reasons that worsen the course of COVID-19 in patients with DM are features of DM and mutual influence of DM and COVID-19; the influence of separate medicines groups used in the treatment of both diseases; shortcomings in the organization of patients' treatment and care. The main factor that is crucial in the management of these patients is the normalization of blood sugar level and carbohydrates metabolism achieved by all possible means.