Literature DB >> 3327017

Glycine potentiates N-methyl-D-aspartate-induced [3H]TCP binding to rat cortical membranes.

L D Snell1, R S Morter, K M Johnson.   

Abstract

In extensively washed preparations of rat cortical membranes, N-methyl-D-aspartate (NMDA) increases the specific binding of [3H]TCP by over 4-fold in a concentration dependent manner (EC50 = 3.1 microM). Glycine (1 microM) potentiates the maximal effect of NMDA by a factor of 1.7. The effect of glycine is concentration dependent (EC50 = 380 nM) and strychnine insensitive. These data are discussed with reference to the recently reported effects of glycine on the NMDA operated cation channel and the relationship between the PCP and NMDA receptors.

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Year:  1987        PMID： 3327017     DOI： 10.1016/0304-3940(87)90106-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

Review 1.  A review of the in vitro and in vivo neurochemical characterization of the NMDA/PCP/glycine/ion channel receptor macrocomplex.

Authors:  P L Wood; T S Rao; S Iyengar; T Lanthorn; J Monahan; A Cordi; E Sun; M Vazquez; N Gray; P Contreras
Journal:  Neurochem Res       Date:  1990-02       Impact factor: 3.996

2.  Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.

Authors:  J J Feigenbaum; F Bergmann; S A Richmond; R Mechoulam; V Nadler; Y Kloog; M Sokolovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

3.  Effects of membrane fluidity on [3H]TCP binding to PCP receptors.

Authors:  F R DePietro; J C Byrd
Journal:  J Mol Neurosci       Date:  1990       Impact factor: 3.444

4.  Interaction of [3H]MK-801 with multiple states of the N-methyl-D-aspartate receptor complex of rat brain.

Authors:  D C Javitt; S R Zukin
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

5.  Phencyclidine treatment in mice: effects on phencyclidine binding sites and glutamate uptake in cerebral cortex preparations.

Authors:  P Saransaari; S M Lillrank; S S Oja
Journal:  J Neural Transm Gen Sect       Date:  1993

6.  Actions of ketamine, phencyclidine and MK-801 on NMDA receptor currents in cultured mouse hippocampal neurones.

Authors:  J F MacDonald; M C Bartlett; I Mody; P Pahapill; J N Reynolds; M W Salter; J H Schneiderman; P S Pennefather
Journal:  J Physiol       Date:  1991-01       Impact factor: 5.182

7.  Antipsychotic agents antagonize non-competitive N-methyl-D-aspartate antagonist-induced behaviors.

Authors:  R Corbett; F Camacho; A T Woods; L L Kerman; R J Fishkin; K Brooks; R W Dunn
Journal:  Psychopharmacology (Berl)       Date:  1995-07       Impact factor: 4.530
  7 in total

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