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Literature DB >> 3326987

The iatrogenic leukaemias induced by radio- and/or chemotherapy.

Abstract

A short review, limited to recently published series of data, has been compiled on the 'therapy-induced' secondary malignancies. Their frequency, peak of incidence, haematological and clinical criteria, the influence of age, treated primary disease, choice of drug(s) and modality of prescription and the role of genetic and environmental factors are analyzed. The risk varies between 0.6 and 20.5% after different treatment forms. Some suggestions for the choice of treatment of chronic malignant disorders, and for the design of future epidemiological studies are given.

Entities: Disease

Mesh：

Substances：
Antineoplastic Agents

Year: 1987 PMID： 3326987 DOI： 10.1007/bf02934521

Source DB: PubMed Journal: Med Oncol Tumor Pharmacother ISSN： 0736-0118

62 in total

1. Childhood leukaemia in the West Berkshire and Basingstoke and North Hampshire District Health Authorities in relation to nuclear establishments in the vicinity.

Authors: E Roman; V Beral; L Carpenter; A Watson; C Barton; H Ryder; D L Aston
Journal: Br Med J (Clin Res Ed) Date: 1987-03-07

2. Effective chemotherapy of acute myelocytic leukemia occurring after alkylating agent or radiation therapy for prior malignancy.

Authors: W P Vaughan; J E Karp; P J Burke
Journal: J Clin Oncol Date: 1983-03 Impact factor: 44.544

10. Treatment of polycythaemia vera by radiophosphorus or busulphan: a randomized trial. "Leukemia and Hematosarcoma" Cooperative Group, European Organization for Research on Treatment of Cancer (E.O.R.T.C.).

Authors:
Journal: Br J Cancer Date: 1981-07 Impact factor: 7.640

1 in total

Review 1. Chemoprotection of normal tissues by transfer of drug resistance genes.

Authors: J A Rafferty; I Hickson; N Chinnasamy; L S Lashford; G P Margison; T M Dexter; L J Fairbairn
Journal: Cancer Metastasis Rev Date: 1996-09 Impact factor: 9.264

1 in total

The iatrogenic leukaemias induced by radio- and/or chemotherapy.

1. Childhood leukaemia in the West Berkshire and Basingstoke and North Hampshire District Health Authorities in relation to nuclear establishments in the vicinity.

2. Effective chemotherapy of acute myelocytic leukemia occurring after alkylating agent or radiation therapy for prior malignancy.

3. The genetic implications of long-term survival of childhood cancer. A conceptual framework.

4. Therapy-related leukemia: a panmyelosis.

5. Prolonged survival in patients with treatment-related leukemia.

6. Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders.

7. Second neoplasms in patients with Hodgkin's disease following combined modality therapy--the Yale experience.

8. Therapy-related preleukemic syndrome.

9. Cancer following medical irradiation.

10. Treatment of polycythaemia vera by radiophosphorus or busulphan: a randomized trial. "Leukemia and Hematosarcoma" Cooperative Group, European Organization for Research on Treatment of Cancer (E.O.R.T.C.).

Review 1. Chemoprotection of normal tissues by transfer of drug resistance genes.