Sahra Esmkhani1, Hossein Sadeghi2, Majid Ghasemian3, Reihaneh Pirjani4, Mona Amin-Beidokhti5, Milad Gholami6, Fakhrolmolouk Yassaee7, Reza Mirfakhraie5. 1. Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran. 2. Genomic Research Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran. 3. Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran. 4. Obstetrics and Gynecology Department, Arash Women Hospital, Tehran University of Medical Sciences , Tehran, Iran. 5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran. 6. Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences , Arak, Iran. 7. Department of Obstetrics and Gynecology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences , Tehran, Iran.
Abstract
Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.
Objective: To investigate the possible association of lncRNA HOTAIRrs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results:HOTAIRrs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIRrs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.
Entities:
Keywords:
HOTAIR ; Preeclampsia; genetic association study; long noncoding-RNA; single nucleotide polymorphism