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Literature DB >> 33261717

Limited Specificity of Serologic Tests for SARS-CoV-2 Antibody Detection, Benin.

Anges Yadouleton, Anna-Lena Sander, Andres Moreira-Soto, Carine Tchibozo, Gildas Hounkanrin, Yvette Badou, Carlo Fischer, Nina Krause, Petas Akogbeto, Edmilson F de Oliveira Filho, Anges Dossou, Sebastian Brünink, Melchior A Joël Aïssi, Mamoudou Harouna Djingarey, Benjamin Hounkpatin, Michael Nagel, Jan Felix Drexler.

Abstract

We used commercially available ELISAs to test 68 samples from coronavirus disease cases and prepandemic controls from Benin. We noted <25% false-positive results among controls, likely due to unspecific immune responses elicited by acute malaria. Serologic tests must be carefully evaluated to assess coronavirus disease spread and immunity in tropical regions.

Entities: Chemical

Keywords: Benin; COVID-19; SARS; SARS-CoV-2; West Africa; coronavirus; coronavirus disease; malaria; parasites; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses

Mesh：

Substances：
Antibodies, Viral

Year: 2020 PMID： 33261717 PMCID： PMC7774555 DOI： 10.3201/eid2701.203281

Source DB: PubMed Journal: Emerg Infect Dis ISSN： 1080-6040 Impact factor: 6.883

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