Literature DB >> 33259653

The emerging role of immunotherapy for the treatment of sarcoma.

Nicholas D Klemen1, Ciara M Kelly2, Edmund K Bartlett1.   

Abstract

Clinicians caring for patients with sarcoma founded the field of cancer immunotherapy. Despite this, contemporary success with immunotherapy for sarcoma has been limited. Here, we review immunotherapy for sarcoma including Coley's toxins, interleukin-2, adoptive cell transfer, and checkpoint blockade. We detail recent and ongoing efforts to combine checkpoint blockade with other immune modulators, surgery, or radiation. These results, along with ongoing investigations, have identified immunotherapeutic approaches as a promising avenue for progress in advanced sarcomas.
© 2020 Wiley Periodicals LLC.

Entities:  

Keywords:  bone sarcoma; checkpoint inhibition; immunotherapy; sarcomas; soft-tissue sarcoma

Mesh：

Substances：

Year:  2020        PMID： 33259653      PMCID： PMC9212861          DOI： 10.1002/jso.26306

Source DB:  PubMed          Journal:  J Surg Oncol        ISSN： 0022-4790            Impact factor:   2.885


  75 in total

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Authors:  J B Murphy; J J Morton
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2.  Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma.

Authors:  Chrystal U Louis; Barbara Savoldo; Gianpietro Dotti; Martin Pule; Eric Yvon; G Doug Myers; Claudia Rossig; Heidi V Russell; Oumar Diouf; Enli Liu; Hao Liu; Meng-Fen Wu; Adrian P Gee; Zhuyong Mei; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
Journal:  Blood       Date:  2011-10-07       Impact factor: 22.113

3.  Bempegaldesleukin (NKTR-214) plus Nivolumab in Patients with Advanced Solid Tumors: Phase I Dose-Escalation Study of Safety, Efficacy, and Immune Activation (PIVOT-02).

Authors:  Adi Diab; Nizar M Tannir; Salah-Eddine Bentebibel; Chantale Bernatchez; Michael E Hurwitz; Daniel C Cho; Patrick Hwu; Vassiliki Papadimitrakopoulou; Cara Haymaker; Harriet M Kluger; Scott N Gettinger; Mario Sznol; Scott S Tykodi; Brendan D Curti; Mary A Tagliaferri; Jonathan Zalevsky; Alison L Hannah; Ute Hoch; Sandra Aung; Christie Fanton; Ahsan Rizwan; Ernesto Iacucci; Yijie Liao
Journal:  Cancer Discov       Date:  2020-05-21       Impact factor: 39.397

4.  Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

Authors:  Suzanne L Topalian; F Stephen Hodi; Julie R Brahmer; Scott N Gettinger; David C Smith; David F McDermott; John D Powderly; Richard D Carvajal; Jeffrey A Sosman; Michael B Atkins; Philip D Leming; David R Spigel; Scott J Antonia; Leora Horn; Charles G Drake; Drew M Pardoll; Lieping Chen; William H Sharfman; Robert A Anders; Janis M Taube; Tracee L McMiller; Haiying Xu; Alan J Korman; Maria Jure-Kunkel; Shruti Agrawal; Daniel McDonald; Georgia D Kollia; Ashok Gupta; Jon M Wigginton; Mario Sznol
Journal:  N Engl J Med       Date:  2012-06-02       Impact factor: 91.245

5.  Localized extremity soft tissue sarcoma: improved knowledge with unchanged survival over time.

Authors:  Jürgen Weitz; Christina R Antonescu; Murray F Brennan
Journal:  J Clin Oncol       Date:  2003-07-15       Impact factor: 44.544

6.  Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas.

Authors:  R D Lindberg; R G Martin; M M Romsdahl; H T Barkley
Journal:  Cancer       Date:  1981-05-15       Impact factor: 6.860

7.  B cells are associated with survival and immunotherapy response in sarcoma.

Authors:  Florent Petitprez; Aurélien de Reyniès; Emily Z Keung; Tom Wei-Wu Chen; Cheng-Ming Sun; Julien Calderaro; Yung-Ming Jeng; Li-Ping Hsiao; Laetitia Lacroix; Antoine Bougoüin; Marco Moreira; Guillaume Lacroix; Ivo Natario; Julien Adam; Carlo Lucchesi; Yec Han Laizet; Maud Toulmonde; Melissa A Burgess; Vanessa Bolejack; Denise Reinke; Khalid M Wani; Wei-Lien Wang; Alexander J Lazar; Christina L Roland; Jennifer A Wargo; Antoine Italiano; Catherine Sautès-Fridman; Hussein A Tawbi; Wolf H Fridman
Journal:  Nature       Date:  2020-01-15       Impact factor: 49.962

8.  Comprehensive molecular characterization of clear cell renal cell carcinoma.

Authors: 
Journal:  Nature       Date:  2013-06-23       Impact factor: 49.962

9.  Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma.

Authors:  Nicholas D Klemen; Paul L Feingold; Stephanie L Goff; Marybeth S Hughes; Udai S Kammula; James C Yang; David S Schrump; Steven A Rosenberg; Richard M Sherry
Journal:  Ann Surg Oncol       Date:  2016-09-16       Impact factor: 5.344

10.  Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab: A Phase 2 Clinical Trial.

Authors:  Ciara M Kelly; Cristina R Antonescu; Timothy Bowler; Rodrigo Munhoz; Ping Chi; Mark A Dickson; Mrinal M Gounder; Mary Louise Keohan; Sujana Movva; Reena Dholakia; Hamza Ahmad; Matthew Biniakewitz; Mercedes Condy; Haley Phelan; Margaret Callahan; Phillip Wong; Sam Singer; Charlotte Ariyan; Edmund K Bartlett; Aimee Crago; Sam Yoon; Sinchun Hwang; Joseph P Erinjeri; Li-Xuan Qin; William D Tap; Sandra P D'Angelo
Journal:  JAMA Oncol       Date:  2020-03-01       Impact factor: 33.006
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  5 in total

1.  Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma.

Authors:  Nicholas D Klemen; Sinchun Hwang; Martina Bradic; Evan Rosenbaum; Mark A Dickson; Mrinal M Gounder; Ciara M Kelly; Mary L Keohan; Sujana Movva; Katherine A Thornton; Ping Chi; Benjamin A Nacev; Jason E Chan; Edmund K Bartlett; Allison L Richards; Samuel Singer; Mark T A Donoghue; William D Tap; Sandra P D'Angelo
Journal:  Clin Cancer Res       Date:  2022-03-01       Impact factor: 12.531

2.  The Role of Radiotherapy in Soft Tissue Sarcoma on Extremities With Lymph Nodes Metastasis: An IPTW Propensity Score Analysis of the SEER Database.

Authors:  Xinzhu Qiu; Hongbo He; Hao Zeng; Xiaopeng Tong; Qing Liu
Journal:  Front Oncol       Date:  2021-10-21       Impact factor: 6.244

3.  Case Report: Response to Regional Melphalan via Limb Infusion and Systemic PD1 Blockade in Recurrent Myxofibrosarcoma: A Report of 2 Cases.

Authors:  Edmund K Bartlett; Sandra P D'Angelo; Ciara M Kelly; Robert H Siegelbaum; Charles Fisher; Cristina R Antonescu; Charlotte E Ariyan
Journal:  Front Oncol       Date:  2021-10-15       Impact factor: 5.738

4.  VISTA in Soft Tissue Sarcomas: A Perspective for Immunotherapy?

Authors:  Markus Albertsmeier; Annelore Altendorf-Hofmann; Lars H Lindner; Rolf D Issels; Eric Kampmann; Hans-Roland Dürr; Martin K Angele; Frederick Klauschen; Jens Werner; Achim A Jungbluth; Thomas Knösel
Journal:  Cancers (Basel)       Date:  2022-02-16       Impact factor: 6.639

Review 5.  Histamine in cancer immunology and immunotherapy. Current status and new perspectives.

Authors:  María de la Paz Sarasola; Mónica A Táquez Delgado; Melisa B Nicoud; Vanina A Medina
Journal:  Pharmacol Res Perspect       Date:  2021-10
  5 in total

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