Philip D Poorvu1, Shari I Gelber2, Yue Zheng2, Kathryn J Ruddy3, Rulla M Tamimi4, Jeffrey Peppercorn5, Lidia Schapira6, Virginia F Borges7, Steven E Come8, Matteo Lambertini9,10, Shoshana M Rosenberg1,11, Ann H Partridge1. 1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. 2. Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts. 3. Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota. 4. Department of Population Health Sciences, Weill Cornell Medicine, New York, New York. 5. Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. 6. Stanford University, Palo Alto, California. 7. Department of Medical Oncology, University of Colorado Cancer Center, Aurora, Colorado. 8. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts. 9. Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. 10. Medical Oncology Clinic, IRCCS San Maritino Polyclinic Hospital, Genoa, Italy. 11. Social and Behavioral Sciences, Harvard School of Public Health, Boston, Massachusetts.
Abstract
BACKGROUND: Many young women with newly diagnosed breast cancer are interested in future pregnancies. Prospective data regarding fertility interest and reproductive patterns after diagnosis are needed to counsel patients. METHODS: The Young Women's Breast Cancer Study is a multicenter, prospective cohort of women who were diagnosed with breast cancer at age ≤40 years between 2006 and 2016. Women complete surveys at baseline, every 6 months for 3 years, then annually. Here, the authors describe fertility interest and pregnancies within 5 years of diagnosis for women with stage 0 through III breast cancer. RESULTS: Of 1026 eligible participants, 368 (36%) reported interest in future biologic children at least once within 5 years after diagnosis, including 16% at 5 years after diagnosis. Among 130 women who attempted to become pregnant, 90 (69.2%) conceived; and, among 896 women who did not attempt to conceive, 18 (2.0%) became pregnant, with a total of 152 pregnancies resulting in 91 live births. Factors associated with pregnancy included younger versus older age at diagnosis (aged ≤30 vs 36-40 years: odds ratio [OR], 6.63; 95% CI, 3.18-13.83; P < .0001; aged 31-35 vs 36-40 years: OR, 5.86; 95% CI, 3.37-10.17; P < .0001) and being nulliparous versus parous (OR, 2.66; 95% CI, 1.56-4.53; P = .001). The receipt of endocrine therapy versus no endocrine therapy (OR, 0.35; 95% CI, 0.20-0.59; P = .001) was inversely associated with pregnancy. CONCLUSIONS: Many women remain interested in future fertility in the 4 years after a breast cancer diagnosis, indicating that longitudinal fertility discussions are needed. Although a minority of those interested in having children attempted to become pregnant in the first 5 years, most who attempted to conceive did so and had live births.
BACKGROUND: Many young women with newly diagnosed breast cancer are interested in future pregnancies. Prospective data regarding fertility interest and reproductive patterns after diagnosis are needed to counsel patients. METHODS: The Young Women's Breast Cancer Study is a multicenter, prospective cohort of women who were diagnosed with breast cancer at age ≤40 years between 2006 and 2016. Women complete surveys at baseline, every 6 months for 3 years, then annually. Here, the authors describe fertility interest and pregnancies within 5 years of diagnosis for women with stage 0 through III breast cancer. RESULTS: Of 1026 eligible participants, 368 (36%) reported interest in future biologic children at least once within 5 years after diagnosis, including 16% at 5 years after diagnosis. Among 130 women who attempted to become pregnant, 90 (69.2%) conceived; and, among 896 women who did not attempt to conceive, 18 (2.0%) became pregnant, with a total of 152 pregnancies resulting in 91 live births. Factors associated with pregnancy included younger versus older age at diagnosis (aged ≤30 vs 36-40 years: odds ratio [OR], 6.63; 95% CI, 3.18-13.83; P < .0001; aged 31-35 vs 36-40 years: OR, 5.86; 95% CI, 3.37-10.17; P < .0001) and being nulliparous versus parous (OR, 2.66; 95% CI, 1.56-4.53; P = .001). The receipt of endocrine therapy versus no endocrine therapy (OR, 0.35; 95% CI, 0.20-0.59; P = .001) was inversely associated with pregnancy. CONCLUSIONS: Many women remain interested in future fertility in the 4 years after a breast cancer diagnosis, indicating that longitudinal fertility discussions are needed. Although a minority of those interested in having children attempted to become pregnant in the first 5 years, most who attempted to conceive did so and had live births.
Authors: Clare Meernik; Stephanie M Engel; Ally Wardell; Christopher D Baggett; Parul Gupta; Nidia Rodriguez-Ormaza; Barbara Luke; Valerie L Baker; Ethan Wantman; Jose Alejandro Rauh-Hain; Jennifer E Mersereau; Andrew F Olshan; Andrew B Smitherman; Jianwen Cai; Hazel B Nichols Journal: J Cancer Surviv Date: 2022-02-16 Impact factor: 4.062
Authors: Marie-Madeleine Dolmans; Isabelle Demeestere; Ellen Anckaert; Michel De Vos Journal: J Assist Reprod Genet Date: 2022-06-25 Impact factor: 3.357
Authors: Matteo Lambertini; Claudia Massarotti; Julie Havas; Barbara Pistilli; Anne-Laure Martin; Alexandra Jacquet; Charles Coutant; Florence Coussy; Asma Dhaini Mérimèche; Florence Lerebours; Christine Rousset-Jablonski; Christelle Jouannaud; Olivier Rigal; Marion Fournier; Patrick Soulie; Maria Alice Franzoi; Lucia Del Mastro; Ann H Partridge; Fabrice André; Ines Vaz-Luis; Antonio Di Meglio Journal: JAMA Netw Open Date: 2022-09-01