Literature DB >> 3325884

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma.

Y Tsujimoto1, N Ikegaki, C M Croce.   

Abstract

A protein corresponding in size to the bcl-2 alpha protein obtained after in vitro transcription and in vitro translation in a rabbit reticulocyte lysate was specifically immunoprecipitated from a human B-cell extract using rabbit polyclonal antiserum raised against a beta-galactosidase/bcl-2 fusion protein. Peptide mapping with V8 protease confirmed the identity of this protein as human bcl-2 alpha. Subcellular fractionation of cellular protein followed by immunoprecipitation showed that the bcl-2 alpha protein is associated with the cell membrane.

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Year:  1987        PMID： 3325884

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  37 in total

1.  Expression of the bcl-2 gene product in follicular lymphoma.

Authors:  P Gaulard; M F d'Agay; M Peuchmaur; N Brousse; C Gisselbrecht; P Solal-Celigny; J Diebold; D Y Mason
Journal:  Am J Pathol       Date:  1992-05       Impact factor: 4.307

2.  Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif.

Authors:  Jingzhen Ding; Zhi Zhang; G Jane Roberts; Mina Falcone; Yiwei Miao; Yuanlong Shao; Xuejun C Zhang; David W Andrews; Jialing Lin
Journal:  J Biol Chem       Date:  2010-06-28       Impact factor: 5.157

3.  Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

Authors:  Y T Hsu; K G Wolter; R J Youle
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

4.  Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts.

Authors:  J C Reed; S Haldar; C M Croce; M P Cuddy
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

5.  Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

Authors:  Y Yamanashi; S Mori; M Yoshida; T Kishimoto; K Inoue; T Yamamoto; K Toyoshima
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

Review 6.  Finally, An Apoptosis-Targeting Therapeutic for Cancer.

Authors:  Carlo M Croce; John C Reed
Journal:  Cancer Res       Date:  2016-09-30       Impact factor: 12.701

7.  bcl-2 protein in invasive ductal breast carcinomas.

Authors:  J Hurlimann; B Larrinaga; D L Vala
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

8.  Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice.

Authors:  R C Bargou; C Wagener; K Bommert; M Y Mapara; P T Daniel; W Arnold; M Dietel; H Guski; A Feller; H D Royer; B Dörken
Journal:  J Clin Invest       Date:  1996-06-01       Impact factor: 14.808

9.  Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

Authors:  A Strasser; S Whittingham; D L Vaux; M L Bath; J M Adams; S Cory; A W Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

10.  Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line.

Authors:  Yasuhiro Inoue; Chikao Miki; Hideki Watanabe; Junichiro Hiro; Yuji Toiyama; Eiki Ojima; Hidenori Yanagi; Masato Kusunoki
Journal:  J Gastroenterol       Date:  2007-02-06       Impact factor: 7.527
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