Literature DB >> 3325881

Novel transforming sequences in human acute myelocytic leukemia cell lines.

J W Janssen1, A C Steenvoorden, M Losekoot, C R Bartram.   

Abstract

DNA transfection analyses using the tumorigenicity assay were performed on seven human acute myelocytic leukemia (AML) cell lines. DNAs from all cell lines induced tumors in nude mice. Respective transforming sequences could be identified as activated N-ras genes in AML cell lines THP-1, KG-1 and Rc2a. We observed the transfer of five putative novel transforming sequences from DNAs of cell lines U937, ML-1, HEL and CTV-2. These sequences appear to be unrelated to each other and previously known oncogenes. Transfections containing these transforming genes show distinctive biological and morphological characteristics. Our data suggest that the transforming sequences reported here became activated during the transfection process rather than the AML cell line.

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Year:  1987        PMID： 3325881

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  3 in total

1.  Incidence of ras gene mutations in neuroblastoma.

Authors:  K Ballas; J Lyons; J W Janssen; C R Bartram
Journal:  Eur J Pediatr       Date:  1988-04       Impact factor: 3.183

2.  RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes.

Authors:  J W Janssen; A C Steenvoorden; J Lyons; B Anger; J U Böhlke; J L Bos; H Seliger; C R Bartram
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation.

Authors:  Daniel J Gough; Lisa Koetz; David E Levy
Journal:  PLoS One       Date:  2013-11-29       Impact factor: 3.240
  3 in total

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