| Literature DB >> 33258461 |
K Grace Foley1, Michele T Pritchard2, Francesca E Duncan1.
Abstract
Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.Entities:
Mesh:
Year: 2021 PMID: 33258461 PMCID: PMC7856073 DOI: 10.1530/REP-20-0489
Source DB: PubMed Journal: Reproduction ISSN: 1470-1626 Impact factor: 3.906