Literature DB >> 33258461

Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.

K Grace Foley1, Michele T Pritchard2, Francesca E Duncan1.   

Abstract

Inflammaging is a state of chronic, low-grade inflammation associated with aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.

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Year:  2021        PMID: 33258461      PMCID: PMC7856073          DOI: 10.1530/REP-20-0489

Source DB:  PubMed          Journal:  Reproduction        ISSN: 1470-1626            Impact factor:   3.906


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