| Literature DB >> 33257876 |
Jenny Meinhardt1, Josefine Radke1,2,3, Carsten Dittmayer1, Jonas Franz4,5,6, Carolina Thomas4,6, Ronja Mothes1, Michael Laue7, Julia Schneider8, Sebastian Brünink8, Selina Greuel9, Malte Lehmann10, Olga Hassan1, Tom Aschman1, Elisa Schumann1,3, Robert Lorenz Chua11, Christian Conrad11, Roland Eils11,12, Werner Stenzel1, Marc Windgassen13, Larissa Rößler13, Hans-Hilmar Goebel1, Hans R Gelderblom7, Hubert Martin1, Andreas Nitsche7, Walter J Schulz-Schaeffer14, Samy Hakroush15, Martin S Winkler16, Björn Tampe17, Franziska Scheibe18,19, Péter Körtvélyessy18,20, Dirk Reinhold21, Britta Siegmund10, Anja A Kühl22, Sefer Elezkurtaj9, David Horst9, Lars Oesterhelweg13, Michael Tsokos13, Barbara Ingold-Heppner23, Christine Stadelmann4, Christian Drosten8, Victor Max Corman8, Helena Radbruch1, Frank L Heppner24,25,26,27.
Abstract
The newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been described. Given the neurological symptoms observed in a large majority of individuals with COVID-19, SARS-CoV-2 penetrance of the CNS is likely. By various means, we demonstrate the presence of SARS-CoV-2 RNA and protein in anatomically distinct regions of the nasopharynx and brain. Furthermore, we describe the morphological changes associated with infection such as thromboembolic ischemic infarction of the CNS and present evidence of SARS-CoV-2 neurotropism. SARS-CoV-2 can enter the nervous system by crossing the neural-mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings. Subsequently, SARS-CoV-2 appears to follow neuroanatomical structures, penetrating defined neuroanatomical areas including the primary respiratory and cardiovascular control center in the medulla oblongata.Entities:
Year: 2020 PMID： 33257876 DOI： 10.1038/s41593-020-00758-5
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884