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Literature DB >> 3325643

Methotrexate pneumonitis in rheumatoid arthritis: potential risk factors. Four case reports and a review of the literature.

Abstract

Methotrexate pneumonitis is emerging as one of the most unpredictable and potentially serious adverse effects associated with the use of low dose, pulse methotrexate in treating rheumatoid arthritis (RA). We report 4 new cases of methotrexate pneumonitis in patients with RA and review 6 published cases. A greater than expected proportion of patients had a smoking history, preexisting pulmonary disease and were male. Prognosis was better in those patients treated with corticosteroids.

Entities: Chemical Disease Species

Mesh：

Substances：
Methotrexate

Year: 1987 PMID： 3325643

Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666

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Cited

38 in total

1. How common is methotrexate pneumonitis? A large prospective study investigates.

Authors: Navtej Sathi; Batsirai Chikura; Viswanath V Kaushik; Rose Wiswell; Julie K Dawson
Journal: Clin Rheumatol Date: 2011-06-03 Impact factor: 2.980

2. Methotrexate, pneumonitis, and infection.

Authors: A A Stenger; P M Houtman
Journal: Ann Rheum Dis Date: 1992-10 Impact factor: 19.103

3. Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma.

Authors: Mehmet Sirmali; Levent Ozçakar; Göktürk Findik; Ayşen Akinci; Sadi Kaya
Journal: Rheumatol Int Date: 2003-10-31 Impact factor: 2.631

4. Leflunomide in combination therapy for rheumatoid arthritis.

Authors: Ruth L Savage
Journal: Drug Saf Date: 2010-06-01 Impact factor: 5.606

5. Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.

Authors: Hideto Kameda; Ayumi Okuyama; Jun-Ichi Tamaru; Shinji Itoyama; Atsushi Iizuka; Tsutomu Takeuchi
Journal: Clin Rheumatol Date: 2007-01-03 Impact factor: 2.980

10. Pulmonary Adverse Events in Patients Receiving Low-Dose Methotrexate in the Randomized, Double-Blind, Placebo-Controlled Cardiovascular Inflammation Reduction Trial.

Authors: Jeffrey A Sparks; Paul F Dellaripa; Robert J Glynn; Nina P Paynter; Chang Xu; Paul M Ridker; Daniel H Solomon
Journal: Arthritis Rheumatol Date: 2020-10-07 Impact factor: 10.995

Methotrexate pneumonitis in rheumatoid arthritis: potential risk factors. Four case reports and a review of the literature.

1. How common is methotrexate pneumonitis? A large prospective study investigates.

2. Methotrexate, pneumonitis, and infection.

3. Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma.

4. Leflunomide in combination therapy for rheumatoid arthritis.

5. Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis.

6. Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoid arthritis.

Review 7. Efficacy of methotrexate in ulcerative colitis: failure or promise.

8. Methotrexate pneumonitis in a patient with rheumatoid arthritis.

9. Pulmonary echography in systemic sclerosis.

10. Pulmonary Adverse Events in Patients Receiving Low-Dose Methotrexate in the Randomized, Double-Blind, Placebo-Controlled Cardiovascular Inflammation Reduction Trial.