Literature DB >> 3325583

Multiplication of Mycobacterium leprae in the nude mouse, and some applications of nude mice to experimental leprosy.

R D McDermott-Lancaster1, T Ito, K Kohsaka, C C Guelpa-Lauras, J H Grosset.   

Abstract

Two aspects of the immune deficiency of nude mice make these animals particularly useful tools for leprosy research. Nude mice are capable of supporting multiplication of M. leprae to levels approaching 10(10) per g in peripheral body tissues. In addition, nude mice may be inoculated with greater than 10(4) (in fact, with as many as 10(8) organisms per foot pad, without provoking an immune response that prevents multiplication of the organisms. Thus, the nude mouse should be particularly suitable for detecting persisting M. leprae in treated patients, and as a model of the patient for evaluating chemotherapeutic regimens.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3325583

Source DB:  PubMed          Journal:  Int J Lepr Other Mycobact Dis        ISSN： 0148-916X


  6 in total

1.  Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice.

Authors:  B Ji; E G Perani; C Petinom; J H Grosset
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

2.  Inhibition of the multiplication of Mycobacterium leprae by vaccination with a recombinant M. bovis BCG strain that secretes major membrane protein II in mice.

Authors:  Y Maeda; T Tamura; M Matsuoka; M Makino
Journal:  Clin Vaccine Immunol       Date:  2009-08-12

3.  A lipopeptide facilitate induction of Mycobacterium leprae killing in host cells.

Authors:  Yumi Maeda; Toshiki Tamura; Yasuo Fukutomi; Tetsu Mukai; Masanori Kai; Masahiko Makino
Journal:  PLoS Negl Trop Dis       Date:  2011-11-22

4.  Mycobacterium leprae-Infected Macrophages Preferentially Primed Regulatory T Cell Responses and Was Associated with Lepromatous Leprosy.

Authors:  Degang Yang; Tiejun Shui; Jake W Miranda; Danny J Gilson; Zhengyu Song; Jia Chen; Chao Shi; Jianyu Zhu; Jun Yang; Zhichun Jing
Journal:  PLoS Negl Trop Dis       Date:  2016-01-11

5.  An in vitro model of Mycobacterium leprae induced granuloma formation.

Authors:  Hongsheng Wang; Yumi Maeda; Yasuo Fukutomi; Masahiko Makino
Journal:  BMC Infect Dis       Date:  2013-06-20       Impact factor: 3.090

6.  Post-exposure prophylaxis (PEP) efficacy of rifampin, rifapentine, moxifloxacin, minocycline, and clarithromycin in a susceptible-subclinical model of leprosy.

Authors:  Shannon M Lenz; Jaymes H Collins; Nashone A Ray; Deanna A Hagge; Ramanuj Lahiri; Linda B Adams
Journal:  PLoS Negl Trop Dis       Date:  2020-09-16
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.