Literature DB >> 33254021

cGAS-STING signaling in cancer immunity and immunotherapy.

Huashan Du1, Tianmin Xu2, Manhua Cui3.   

Abstract

Recent studies have shown that the innate immune cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway may play an important role in antitumor immunity. Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other therapeutic methods provides a new perspective from which to overcome obstacles in the application of this review. Further, we highlight the antitumor mechanism of the cGAS-STING signaling pathway and the latest advances in monotherapy and combination therapy with related agonists.
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Entities:  

Keywords:  Antitumor; Cancer immunity; Cancer therapy; cGAS-STING signaling

Mesh：

Substances：

Year:  2020        PMID： 33254021     DOI： 10.1016/j.biopha.2020.110972

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  10 in total

Review 1.  Advances in plant-derived natural products for antitumor immunotherapy.

Authors:  Yi Yang; Qinying Liu; Xianai Shi; Qiuhong Zheng; Li Chen; Yang Sun
Journal:  Arch Pharm Res       Date:  2021-11-09       Impact factor: 4.946

2.  Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire.

Authors:  Audrey Darmon; Ping Zhang; Julie Marill; Naeemunnisa Mohamed Anesary; Jordan Da Silva; Sébastien Paris
Journal:  Cancer Cell Int       Date:  2022-06-03       Impact factor: 6.429

Review 3.  Novel Therapeutic Opportunities in Neoadjuvant Setting in Urothelial Cancers: A New Horizon Opened by Molecular Classification and Immune Checkpoint Inhibitors.

Authors:  Maria Lucia Iacovino; Chiara Carmen Miceli; Marco De Felice; Biagio Barone; Luca Pompella; Francesco Chiancone; Erika Di Zazzo; Giuseppe Tirino; Carminia Maria Della Corte; Ciro Imbimbo; Ferdinando De Vita; Felice Crocetto
Journal:  Int J Mol Sci       Date:  2022-01-20       Impact factor: 5.923

4.  Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells.

Authors:  Ruben Serrano; Marcus Lettau; Michal Zarobkiewicz; Daniela Wesch; Christian Peters; Dieter Kabelitz
Journal:  Oncoimmunology       Date:  2022-02-01       Impact factor: 8.110

Review 5.  Importance of the Immune Microenvironment in the Spontaneous Regression of Cervical Squamous Intraepithelial Lesions (cSIL) and Implications for Immunotherapy.

Authors:  Caroline L P Muntinga; Peggy J de Vos van Steenwijk; Ruud L M Bekkers; Edith M G van Esch
Journal:  J Clin Med       Date:  2022-03-05       Impact factor: 4.241

6.  Primary Tumor Suppression and Systemic Immune Activation of Macrophages through the Sting Pathway in Metastatic Skin Tumor.

Authors:  Chun-Bong Synn; Dong Kwon Kim; Jae Hwan Kim; Youngseon Byeon; Young Seob Kim; Mi Ran Yun; Ji Min Lee; Wongeun Lee; Eun Ji Lee; Seul Lee; You-Won Lee; Doo Jae Lee; Hyun-Woo Kim; Chang Gon Kim; Min Hee Hong; June Dong Park; Sun Min Lim; Kyoung-Ho Pyo
Journal:  Yonsei Med J       Date:  2022-01       Impact factor: 2.759

Review 7.  Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections.

Authors:  Lishuang Deng; Zhiwen Xu; Fengqin Li; Jun Zhao; Zhijie Jian; Huidan Deng; Siyuan Lai; Xiangang Sun; Yi Geng; Ling Zhu
Journal:  Front Immunol       Date:  2022-07-01       Impact factor: 8.786

8.  PCBP2 Reduced Oxidative Stress-Induced Apoptosis in Glioma through cGAS/STING Pathway by METTL3-Mediated m6A Modification.

Authors:  Xiang Chen; Mingchuan Yu; Wei Xu; Peng Kun; Wenbing Wan; Xiao Yuhong; Jing Ye; Yu Liu; Jun Luo
Journal:  Oxid Med Cell Longev       Date:  2022-10-11       Impact factor: 7.310

Review 9.  Mechanisms of Immune Escape and Resistance to Checkpoint Inhibitor Therapies in Mismatch Repair Deficient Metastatic Colorectal Cancers.

Authors:  Vito Amodio; Gianluca Mauri; Nicole M Reilly; Andrea Sartore-Bianchi; Salvatore Siena; Alberto Bardelli; Giovanni Germano
Journal:  Cancers (Basel)       Date:  2021-05-27       Impact factor: 6.639

10.  Development of Small-Molecule STING Activators for Cancer Immunotherapy.

Authors:  Hee Ra Jung; Seongman Jo; Min Jae Jeon; Hyelim Lee; Yeonjeong Chu; Jeehee Lee; Eunha Kim; Gyu Yong Song; Cheulhee Jung; Hyejin Kim; Sanghee Lee
Journal:  Biomedicines       Date:  2021-12-24
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.