| Literature DB >> 33253551 |
Jessica J King1, Kelly L Irving1, Cameron W Evans1, Rupesh V Chikhale2,3, Rouven Becker2, Christopher J Morris2, Cristian D Peña Martinez4, Peter Schofield4,5, Daniel Christ4,5, Laurence H Hurley6, Zoë A E Waller2,3, K Swaminathan Iyer1, Nicole M Smith1.
Abstract
Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.Entities:
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Year: 2020 PMID： 33253551 DOI： 10.1021/jacs.0c11708
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419