Douglas N Martini1,2, Rosie Morris1, Tara M Madhyastha3, Thomas J Grabowski3, John Oakley4, Shu-Ching Hu4,5, Cyrus P Zabetian4,5, Karen L Edwards6, Amie Hiller1,7, Kathryn Chung1,7, Katrina Ramsey8, Jodi A Lapidus8,9, Brenna Cholerton10, Thomas J Montine10, Joseph F Quinn1,7, Fay B Horak1,7. 1. Department of Neurology, Oregon Health and Science University, Portland. 2. Department of Kinesiology, University of Massachusetts Amherst. 3. Department of Radiology, University of Washington School of Medicine, Seattle. 4. Department of Neurology, University of Washington School of Medicine, Seattle. 5. Veterans Affairs Puget Sound Health Care System, Seattle, Washington. 6. Department of Epidemiology, University of California, Irvine. 7. Portland Veterans Affairs Health Care System, Oregon. 8. Biostatistics & Design Program, Oregon Health and Science University, Portland. 9. School of Public Health, Oregon Health and Science University, Portland. 10. Department of Pathology, Stanford University School of Medicine, Palo Alto, California.
Abstract
BACKGROUND: Reduced cortical sensorimotor inhibition is associated with mobility and cognitive impairments in people with Parkinson's disease (PD) and older adults (OAs). However, there is a lack of clarity regarding the relationships among sensorimotor, cognitive, and mobility impairments. The purpose of this study was to determine how cortical sensorimotor inhibition relates to impairments in mobility and cognition in people with PD and OAs. METHOD: Cortical sensorimotor inhibition was characterized with short-latency afferent inhibition (SAI) in 81 people with PD and 69 OAs. Six inertial sensors recorded single- and dual-task gait and postural sway characteristics during a 2-minute walk and a 1-minute quiet stance. Cognition was assessed across the memory, visuospatial, executive function, attention, and language domains. RESULTS: SAI was significantly impaired in the PD compared to the OA group. The PD group preformed significantly worse across all gait and postural sway tasks. In PD, SAI significantly correlated with single-task foot strike angle and stride length variability, sway area, and jerkiness of sway in the coronal and sagittal planes. In OAs, SAI significantly related to single-task gait speed and stride length, dual-task stride length, and immediate recall (memory domain). No relationship among mobility, cognition, and SAI was observed. CONCLUSIONS: Impaired SAI related to slower gait in OA and to increased gait variability and postural sway in people with PD, all of which have been shown to be related to increased fall risk.
BACKGROUND: Reduced cortical sensorimotor inhibition is associated with mobility and cognitive impairments in people with Parkinson's disease (PD) and older adults (OAs). However, there is a lack of clarity regarding the relationships among sensorimotor, cognitive, and mobility impairments. The purpose of this study was to determine how cortical sensorimotor inhibition relates to impairments in mobility and cognition in people with PD and OAs. METHOD: Cortical sensorimotor inhibition was characterized with short-latency afferent inhibition (SAI) in 81 people with PD and 69 OAs. Six inertial sensors recorded single- and dual-task gait and postural sway characteristics during a 2-minute walk and a 1-minute quiet stance. Cognition was assessed across the memory, visuospatial, executive function, attention, and language domains. RESULTS: SAI was significantly impaired in the PD compared to the OA group. The PD group preformed significantly worse across all gait and postural sway tasks. In PD, SAI significantly correlated with single-task foot strike angle and stride length variability, sway area, and jerkiness of sway in the coronal and sagittal planes. In OAs, SAI significantly related to single-task gait speed and stride length, dual-task stride length, and immediate recall (memory domain). No relationship among mobility, cognition, and SAI was observed. CONCLUSIONS: Impaired SAI related to slower gait in OA and to increased gait variability and postural sway in people with PD, all of which have been shown to be related to increased fall risk.
Authors: Moran Gilat; Peter T Bell; Kaylena A Ehgoetz Martens; Matthew J Georgiades; Julie M Hall; Courtney C Walton; Simon J G Lewis; James M Shine Journal: Neuroimage Date: 2017-03-03 Impact factor: 6.556
Authors: V Di Lazzaro; A Oliviero; E Saturno; M Dileone; F Pilato; R Nardone; F Ranieri; G Musumeci; T Fiorilla; P Tonali Journal: J Physiol Date: 2005-02-17 Impact factor: 5.182
Authors: Martijn L T M Müller; Roger L Albin; Vikas Kotagal; Robert A Koeppe; Peter J H Scott; Kirk A Frey; Nicolaas I Bohnen Journal: Brain Date: 2013-09-20 Impact factor: 13.501
Authors: Rosie Morris; Douglas N Martini; Katrijn Smulders; Valerie E Kelly; Cyrus P Zabetian; Kathleen Poston; Amie Hiller; Kathryn A Chung; Laurice Yang; Shu-Ching Hu; Karen L Edwards; Brenna Cholerton; Thomas J Grabowski; Thomas J Montine; Joseph F Quinn; Fay Horak Journal: Parkinsonism Relat Disord Date: 2019-07-04 Impact factor: 4.891