Literature DB >> 33252546

High Coverage of Antiretroviral Treatment With Annual Home-Based HIV Testing, Follow-up Linkage Services, and Implementation of Test and Start: Findings From the Chókwè Health Demographic Surveillance System, Mozambique, 2014-2019.

Ishani Pathmanathan1, Robert Nelson1, Alzira de Louvado2, Ricardo Thompson3, Sherri Pals1, Isabelle Casavant2, Maria Judite Antonio Cardoso4, Dawud Ujamaa1, Juvêncio Bonzela3, Silvia Mikusova5, Victor Chivurre6, Stelio Tamele7, Katrina Sleeman1, Guoqing Zhang1, Clement Zeh1, Trudy Dobbs1, Adolfo Vubil8, Andrew Auld1, Melissa Briggs-Hagen2, Alfredo Vergara2, Aleny Couto9, Duncan MacKellar1.   

Abstract

BACKGROUND: Early antiretroviral therapy (ART) is necessary for HIV epidemic control and depends on early diagnosis and successful linkage to care. Since 2014, annual household-based HIV testing and counseling and linkage services have been provided through the Chókwè Health and Demographic Surveillance System for residents testing HIV positive in this high HIV-burden district.
METHODS: District-wide Test and Start [T&S, ART for all people living with HIV (PLHIV)] began in August 2016, supported by systematic interventions to improve linkage to care and treatment. Annual rounds (R) of random household surveys were conducted to assess trends in population prevalence of ART use and viral load suppression (<1000 viral RNA copies/mL).
RESULTS: Between R1 (April 2014-April 2015) and R5 (April 2018-Mar 2019), 46,090 (67.2%) of 68,620 residents aged 15-59 years were tested for HIV at home at least once, and 3711 were newly diagnosed with HIV and provided linkage services. Population prevalence of current ART use among PLHIV increased from 65.0% to 87.5% between R1 and R5. ART population prevalence was lowest among men aged 25-34 years (67.8%) and women aged 15-24 (78.0%), and highest among women aged 35-44 years (93.6%) and 45-59 years (93.7%) in R5. Viral load suppression prevalence increased among all PLHIV aged 15-59 years from 52.0% in R1 to 78.3% in R5. DISCUSSION: Between 2014 and 2019, Chókwè Health and Demographic Surveillance System residents surpassed the UNAIDS targets of ≥81% of PLHIV on ART and ≥73% virally suppressed. This achievement supports the combination of efforts from household-based HIV testing and counseling, support for linkage to care and treatment, and continued investments in T&S implementation.
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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Year:  2021        PMID: 33252546      PMCID: PMC7970427          DOI: 10.1097/QAI.0000000000002583

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN: 1525-4135            Impact factor:   3.771


  27 in total

1.  Progress of UNAIDS 90-90-90 targets in a district in KwaZulu-Natal, South Africa, with high HIV burden, in the HIPSS study: a household-based complex multilevel community survey.

Authors:  Anneke Grobler; Cherie Cawood; David Khanyile; Adrian Puren; Ayesha B M Kharsany
Journal:  Lancet HIV       Date:  2017-08-02       Impact factor: 12.767

2.  Unreported antiretroviral use by HIV-1-infected participants enrolling in a prospective research study.

Authors:  Erin M Kahle; Angela Kashuba; Jared M Baeten; Kenneth H Fife; Connie Celum; Andrew Mujugira; Max Essex; Guy De Bruyn; Anna Wald; Deborah Donnell; Grace John-Stewart; Sinead Delany-Moretlwe; Nelly R Mugo; Carey Farquhar; Jairam R Lingappa
Journal:  J Acquir Immune Defic Syndr       Date:  2014-02-01       Impact factor: 3.731

3.  Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial.

Authors:  Niklaus D Labhardt; Isaac Ringera; Thabo I Lejone; Thomas Klimkait; Josephine Muhairwe; Alain Amstutz; Tracy R Glass
Journal:  JAMA       Date:  2018-03-20       Impact factor: 56.272

4.  HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa.

Authors:  Diane V Havlir; Laura B Balzer; Edwin D Charlebois; Tamara D Clark; Dalsone Kwarisiima; James Ayieko; Jane Kabami; Norton Sang; Teri Liegler; Gabriel Chamie; Carol S Camlin; Vivek Jain; Kevin Kadede; Mucunguzi Atukunda; Theodore Ruel; Starley B Shade; Emmanuel Ssemmondo; Dathan M Byonanebye; Florence Mwangwa; Asiphas Owaraganise; Winter Olilo; Douglas Black; Katherine Snyman; Rachel Burger; Monica Getahun; Jackson Achando; Benard Awuonda; Hellen Nakato; Joel Kironde; Samuel Okiror; Harsha Thirumurthy; Catherine Koss; Lillian Brown; Carina Marquez; Joshua Schwab; Geoff Lavoy; Albert Plenty; Erick Mugoma Wafula; Patrick Omanya; Yea-Hung Chen; James F Rooney; Melanie Bacon; Mark van der Laan; Craig R Cohen; Elizabeth Bukusi; Moses R Kamya; Maya Petersen
Journal:  N Engl J Med       Date:  2019-07-18       Impact factor: 91.245

5.  Multicenter evaluation of use of dried blood and plasma spot specimens in quantitative assays for human immunodeficiency virus RNA: measurement, precision, and RNA stability.

Authors:  Don Brambilla; Cheryl Jennings; Grace Aldrovandi; James Bremer; Anne Marie Comeau; Sharon A Cassol; Ruth Dickover; J Brooks Jackson; Jane Pitt; John L Sullivan; Ann Butcher; Lynell Grosso; Patricia Reichelderfer; Susan A Fiscus
Journal:  J Clin Microbiol       Date:  2003-05       Impact factor: 5.948

6.  Botswana's progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey.

Authors:  Tendani Gaolathe; Kathleen E Wirth; Molly Pretorius Holme; Joseph Makhema; Sikhulile Moyo; Unoda Chakalisa; Etienne Kadima Yankinda; Quanhong Lei; Mompati Mmalane; Vlad Novitsky; Lillian Okui; Erik van Widenfelt; Kathleen M Powis; Nealia Khan; Kara Bennett; Hermann Bussmann; Scott Dryden-Peterson; Refeletswe Lebelonyane; Shenaaz El-Halabi; Lisa A Mills; Tafireyi Marukutira; Rui Wang; Eric J Tchetgen Tchetgen; Victor DeGruttola; M Essex; Shahin Lockman
Journal:  Lancet HIV       Date:  2016-03-24       Impact factor: 12.767

7.  Antiretroviral Therapy for the Prevention of HIV-1 Transmission.

Authors:  Myron S Cohen; Ying Q Chen; Marybeth McCauley; Theresa Gamble; Mina C Hosseinipour; Nagalingeswaran Kumarasamy; James G Hakim; Johnstone Kumwenda; Beatriz Grinsztejn; Jose H S Pilotto; Sheela V Godbole; Suwat Chariyalertsak; Breno R Santos; Kenneth H Mayer; Irving F Hoffman; Susan H Eshleman; Estelle Piwowar-Manning; Leslie Cottle; Xinyi C Zhang; Joseph Makhema; Lisa A Mills; Ravindre Panchia; Sharlaa Faesen; Joseph Eron; Joel Gallant; Diane Havlir; Susan Swindells; Vanessa Elharrar; David Burns; Taha E Taha; Karin Nielsen-Saines; David D Celentano; Max Essex; Sarah E Hudelson; Andrew D Redd; Thomas R Fleming
Journal:  N Engl J Med       Date:  2016-07-18       Impact factor: 91.245

8.  Association of Implementation of a Universal Testing and Treatment Intervention With HIV Diagnosis, Receipt of Antiretroviral Therapy, and Viral Suppression in East Africa.

Authors:  Maya Petersen; Laura Balzer; Dalsone Kwarsiima; Norton Sang; Gabriel Chamie; James Ayieko; Jane Kabami; Asiphas Owaraganise; Teri Liegler; Florence Mwangwa; Kevin Kadede; Vivek Jain; Albert Plenty; Lillian Brown; Geoff Lavoy; Joshua Schwab; Douglas Black; Mark van der Laan; Elizabeth A Bukusi; Craig R Cohen; Tamara D Clark; Edwin Charlebois; Moses Kamya; Diane Havlir
Journal:  JAMA       Date:  2017-06-06       Impact factor: 56.272

9.  Progress towards the UNAIDS 90-90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa: a household-based community cross-sectional survey.

Authors:  Helena Huerga; Gilles Van Cutsem; Jihane Ben Farhat; Adrian Puren; Malika Bouhenia; Lubbe Wiesner; Linda Dlamini; David Maman; Tom Ellman; Jean-François Etard
Journal:  BMC Public Health       Date:  2018-03-02       Impact factor: 3.295

10.  Low and Decreasing Prevalence and Rate of False Positive HIV Diagnosis - Chókwè District, Mozambique, 2014-2017.

Authors:  Daniel Shodell; Robert Nelson; Duncan MacKellar; Ricardo Thompson; Isabelle Casavant; Didier Mugabe; Sherri Pals; Dawud Ujamaa; Juvencio Bonzela; Judite Cardoso; Salvador Machava; Carlos Lourenço; Chunfu Yang; Bharat Parekh; Ishani Pathmanathan; Andrew F Auld; Stelio Tamele; Manuel Antonio Ouane; Vania Macome; Noela Chicuecue; Guita Amane; Luciana Kohatsu; Nely Honwana; Stanley Wei; Peter R Kerndt; Edgar Monterroso; Alfredo Vergara
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2018-12-14       Impact factor: 17.586

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