Preethi Ramachandran1, Abhilash Perisetti2, Mahesh Gajendran3, Farla Jean-Louis4, Pardeep Bansal5, Alok Kumar Dwivedi6, Hemant Goyal7. 1. Midamerica Cancer Care, West Kansas City, Missouri. 2. Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas. 3. Texas Tech University, Paul L Foster School of Medicine, El Paso, Texas. 4. Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York. 5. Division of Gastroenterology, Moses Taylor Hospital and Reginal Hospital of Scranton, Scranton, Pennsylvania. 6. Division of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Texas Tech University, Paul L Foster School of Medicine, El Paso, Texas. 7. The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, USA.
Abstract
INTRODUCTION: Severe acute respiratory syndrome coronavirus-2 may escape the inactivation by gastric acid because of hypochlorhydria caused by proton pump inhibitors (PPIs), which could predispose the patients to severe COVID-19. METHODS: We studied the association between prehospitalization PPI exposure and clinical outcomes among hospitalized COVID-19 patients. RESULTS: A total of 295 hospitalized COVID-19 patients were included in the study. 15.6% of hospitalized COVID-19 patients were on PPIs at home. Mortality among PPI-users was 2.3 times higher than non-users, along with 2.3 times higher risk of acute respiratory distress syndrome after adjusting for confounding variables. CONCLUSION: We found that prehospitalization PPI-exposure is independently associated with worse clinical outcomes, including mortality in COVID-19 patients, regardless of the presence of cardiovascular comorbidities.
INTRODUCTION: Severe acute respiratory syndrome coronavirus-2 may escape the inactivation by gastric acid because of hypochlorhydria caused by proton pump inhibitors (PPIs), which could predispose the patients to severe COVID-19. METHODS: We studied the association between prehospitalization PPI exposure and clinical outcomes among hospitalized COVID-19 patients. RESULTS: A total of 295 hospitalized COVID-19 patients were included in the study. 15.6% of hospitalized COVID-19 patients were on PPIs at home. Mortality among PPI-users was 2.3 times higher than non-users, along with 2.3 times higher risk of acute respiratory distress syndrome after adjusting for confounding variables. CONCLUSION: We found that prehospitalization PPI-exposure is independently associated with worse clinical outcomes, including mortality in COVID-19 patients, regardless of the presence of cardiovascular comorbidities.
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