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Literature DB >> 33252234

Dual Catalytic Strategy for Forging sp²-sp³ and sp³-sp³ Architectures via β-Scission of Aliphatic Alcohol Derivatives.

Fei Cong^1,2, Xin-Yang Lv^1,2, Craig S Day^1,2, Ruben Martin^1,3.

Abstract

A dual platform for forging sp2-sp3 and sp3-sp3 carbon bonds via catalytic β-scission of aliphatic alcohol derivatives with both aryl and alkyl halides is disclosed. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization.

Entities: Chemical Gene

Year: 2020 PMID： 33252234 DOI： 10.1021/jacs.0c11172

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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Cited

7 in total

1. Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling.

Authors: David J Charboneau; Haotian Huang; Emily L Barth; Cameron C Germe; Nilay Hazari; Brandon Q Mercado; Mycah R Uehling; Susan L Zultanski
Journal: J Am Chem Soc Date: 2021-11-30 Impact factor: 15.419

2. Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation.

Authors: Johnny Z Wang; Holt A Sakai; David W C MacMillan
Journal: Angew Chem Int Ed Engl Date: 2022-07-19 Impact factor: 16.823

3. Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp³ C-O Bonds in Cyclic Acetals.

Authors: Ciro Romano; Laura Talavera; Enrique Gómez-Bengoa; Ruben Martin
Journal: J Am Chem Soc Date: 2022-06-24 Impact factor: 16.383

Dual Catalytic Strategy for Forging sp²-sp³ and sp³-sp³ Architectures via β-Scission of Aliphatic Alcohol Derivatives.

1. Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling.

2. Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation.

3. Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp³ C-O Bonds in Cyclic Acetals.

4. Catalyst-Free Decarbonylative Trifluoromethylthiolation Enabled by Electron Donor-Acceptor Complex Photoactivation.

5. Dual Nickel/Photoredox-Catalyzed Site-Selective Cross-Coupling of 1,2-Bis-Boronic Esters Enabled by 1,2-Boron Shifts.

6. 1,3-Alkyl Transposition in Allylic Alcohols Enabled by Proton-Coupled Electron Transfer.

7. Photoactive electron donor-acceptor complex platform for Ni-mediated C(sp³)-C(sp²) bond formation.