Literature DB >> 33249329

Drug resistant Tuberculosis: A review.

Jessy Lallungawi Khawbung1, Durbba Nath1, Supriyo Chakraborty2.   

Abstract

Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming counter attack of TB worldwide. However, when it was known that TB can be cured completely, the general public became ignorant towards the infection. The pathogenic organism Mycobacterium tuberculosis continuously evolved to resist the antagonist drugs. This has led to the outbreak of resistant strain that gave rise to "Multi Drug Resistant-Tuberculosis" and "Extensively Drug Resistant Tuberculosis" that can still be cured with a lower success rate. While the mechanism of resistance proceeds further, it ultimately causes unmanageable totally drug resistant TB (TDR-TB). Studying the molecular mechanisms underlying the resistance to drugs would help us grasp the genetics and pathophysiology of the disease. In this review, we present the molecular mechanisms behind Mycobacterium tolerance to drugs and their approach towards the development of multi-drug resistant, extremely drug resistant and totally drug resistant TB.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Drug resistance; MDR-TB; Mycobacterium tuberculosis; TDR-TB; Tuberculosis; XDR-TB

Mesh：

Substances：

Year:  2020        PMID： 33249329     DOI： 10.1016/j.cimid.2020.101574

Source DB:  PubMed          Journal:  Comp Immunol Microbiol Infect Dis        ISSN： 0147-9571            Impact factor:   2.268


  11 in total

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