Alaa Atamna1, Tanya Babich2, Dafi Froimovici3, Dafna Yahav4, Nadav Sorek5, Haim Ben-Zvi5, Leonard Leibovici2, Jihad Bishara4, Tomer Avni6. 1. Infectious Disease Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. Electronic address: a.atamna86@gmail.com. 2. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel; Internal Medicine Department E, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel. 3. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. 4. Infectious Disease Unit, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. 5. Clinical Microbiology Laboratory, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel. 6. Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel; Internal Medicine Department A, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel.
Abstract
INTRODUCTION: Respiratory syncytial virus (RSV) is considered a major pathogen that causes acute influenza-like illness. The objective of this study was to compare the clinical outcomes of patients with laboratory-confirmed RSV and patients with influenza infection. METHODS: Adults hospitalized in Beilinson Hospital (October 2017-April 2018) with laboratory-confirmed RSV or influenza were included. The primary outcome was the composite of RSV/influenza complications: 30-day mortality, pneumonia, mechanical ventilation, vasopressor support, intensive care unit admission, and myocarditis/encephalitis. Secondary outcomes were individual components of the primary outcome, 90-day mortality, 90-day readmission, and length of hospital stay. RESULTS: A total of 639 patients with RSV (n = 113) and influenza (n = 526) were included. The composite primary outcome was 21.4% (136/633), and was higher in RSV patients (30% (34/113) vs 19% (102/526), p = 0.002). Pneumonia was more common in RSV patients (21.2% (24/113) vs 9.1% (48/526), p = 0.001). On multivariable analysis, hypoalbuminemia (odds ratio (OR) 3.3, 95% confidence interval (CI) 2.1-5.3, p < 0.001), reduced room-air saturation (OR 1.1, 95% CI 1.02-1.1, p = 0.001), and infection with RSV (OR 1.67, 95% CI 1.01-2.76, p = 0.046) were predictors of complications. CONCLUSIONS: RSV infection in hospitalized adults resulted in serious respiratory illness with complications that are comparable to those caused by influenza.
INTRODUCTION: Respiratory syncytial virus (RSV) is considered a major pathogen that causes acute influenza-like illness. The objective of this study was to compare the clinical outcomes of patients with laboratory-confirmed RSV and patients with influenza infection. METHODS: Adults hospitalized in Beilinson Hospital (October 2017-April 2018) with laboratory-confirmed RSV or influenza were included. The primary outcome was the composite of RSV/influenza complications: 30-day mortality, pneumonia, mechanical ventilation, vasopressor support, intensive care unit admission, and myocarditis/encephalitis. Secondary outcomes were individual components of the primary outcome, 90-day mortality, 90-day readmission, and length of hospital stay. RESULTS: A total of 639 patients with RSV (n = 113) and influenza (n = 526) were included. The composite primary outcome was 21.4% (136/633), and was higher in RSV patients (30% (34/113) vs 19% (102/526), p = 0.002). Pneumonia was more common in RSV patients (21.2% (24/113) vs 9.1% (48/526), p = 0.001). On multivariable analysis, hypoalbuminemia (odds ratio (OR) 3.3, 95% confidence interval (CI) 2.1-5.3, p < 0.001), reduced room-air saturation (OR 1.1, 95% CI 1.02-1.1, p = 0.001), and infection with RSV (OR 1.67, 95% CI 1.01-2.76, p = 0.046) were predictors of complications. CONCLUSIONS:RSV infection in hospitalized adults resulted in serious respiratory illness with complications that are comparable to those caused by influenza.
Authors: Sara Debes; Jon Birger Haug; Birgitte Freiesleben de Blasio; Jonas Christoffer Lindstrøm; Christine Monceyron Jonassen; Susanne Gjeruldsen Dudman Journal: Front Med (Lausanne) Date: 2022-04-29
Authors: Mackenzie A Hamilton; Ying Liu; Andrew Calzavara; Maria E Sundaram; Mohamed Djebli; Dariya Darvin; Stefan Baral; Rafal Kustra; Jeffrey C Kwong; Sharmistha Mishra Journal: Influenza Other Respir Viruses Date: 2022-05-24 Impact factor: 5.606